Doryx and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doryx (doxycycline hyclate) and Premarin (estrogens, conjugated). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Doryx and Premarin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Doryx?

Doryx has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 901 Doryx users. Check the latest studies of Doryx.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

21 people who take Doryx and Premarin together, and have interactions are studied.

What are the common drug interactions of Doryx and Premarin, by gender? *:

female:

Headache (pain in head)
Neck pain
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Micturition urgency (urgency to pass the urine)
Neuropathy peripheral (surface nerve damage)
Rash erythematous (redness of the skin)
Taste disturbance
Tongue discolouration (colour change of tongue)
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls)

male:

n/a

What are the common drug interactions of Doryx and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Difficulty in micturition (difficulty to urinate)
Drug ineffective
Fatigue (feeling of tiredness)
Neck pain
Urinary tract disorder
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)
Headache (pain in head)
Micturition urgency (urgency to pass the urine)
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls)
Anxiety

60+:

Sinusitis (inflammation of sinus)
Rash erythematous (redness of the skin)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Arterial disorder
Arterial insufficiency (lack of enough blood flow through the arteries)
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 42.86%
Pain: 2 people, 9.52%
Muscle Spasms (muscle contraction): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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