Doxycycline hyclate and Bextra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline hyclate (doxycycline hyclate) and Bextra (valdecoxib). Common drug interactions include mood swings among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline hyclate and Bextra. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline hyclate?

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 17,884 Doxycycline hyclate users. Check the latest studies of Doxycycline hyclate.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

On Jul, 20, 2026

18 people who take Doxycycline hyclate and Bextra together, and have interactions are studied.

Doxycycline hyclate and Bextra drug interactions.

What are the common drug interactions of Doxycycline Hyclate and Bextra, by gender? *:

female:

Mood swings (an extreme or rapid change in mood)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Neuralgia (pain in one or more nerves)
Chronic kidney disease
Asthenia (weakness)
Back pain
Depression
Drug hypersensitivity

male:

Arthralgia (joint pain)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Pancreatic carcinoma (pancreatic cancer)
Renal injury (kidney injury)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Therapeutic response decreased (less preventive response)
Chronic kidney disease
Fall
Femur fracture

What are the common drug interactions of Doxycycline Hyclate and Bextra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Metastases to lymph nodes (cancer spreads to lymph node)
Thyroid cancer metastatic (thyroid cancer spreads to other part)
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

50-59:

Drug hypersensitivity
Femur fracture
Fracture delayed union (delayed cure of broken bone)
Fracture displacement
Fracture nonunion (permanent failure of healing following a broken bone)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Impaired gastric emptying
Nephropathy (damage to or disease of a kidney)
Pain in extremity
Pancreatic carcinoma (pancreatic cancer)

60+:

Drug hypersensitivity
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Arteriosclerosis (thickening and hardening of arteries)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Back pain
Balance disorder
Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
Bradycardia (abnormally slow heart action)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 38.89%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 27.78%
Infection: 5 people, 27.78%
Hypokalemia (low potassium): 4 people, 22.22%
High Blood Pressure: 4 people, 22.22%
Nausea (feeling of having an urge to vomit): 4 people, 22.22%
High Blood Cholesterol: 4 people, 22.22%
Insomnia (sleeplessness): 4 people, 22.22%
Depression: 4 people, 22.22%
Stress And Anxiety: 4 people, 22.22%

* Approximation only. Some reports may have incomplete information.

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