Doxycycline hyclate and Ciprofloxacin hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline hyclate (doxycycline hyclate) and Ciprofloxacin hydrochloride (ciprofloxacin hydrochloride). Common drug interactions include local reaction among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline hyclate and Ciprofloxacin hydrochloride. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline hyclate?

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 17,884 Doxycycline hyclate users. Check the latest studies of Doxycycline hyclate.

What is Ciprofloxacin hydrochloride?

Ciprofloxacin hydrochloride has active ingredients of ciprofloxacin hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 3,281 Ciprofloxacin hydrochloride users. Check the latest studies of Ciprofloxacin hydrochloride.

On Jul, 13, 2026

54 people who take Doxycycline hyclate and Ciprofloxacin hydrochloride together, and have interactions are studied.

Doxycycline hyclate and Ciprofloxacin hydrochloride drug interactions.

What are the common drug interactions of Doxycycline Hyclate and Ciprofloxacin Hydrochloride, by gender? *:

female:

Local reaction (reaction of any substance at the site of use)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pyrexia (fever)
Red blood cell count decreased
Skin infection
Stress
Acarodermatitis (skin inflammation caused by mites (acarids))
Back pain
Chronic kidney disease
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)

male:

Pain
Nausea (feeling of having an urge to vomit)
Pneumonia
Renal failure (kidney dysfunction)
Sinusitis (inflammation of sinus)
Skin tightness
Bone density decreased
Osteoporosis (bones weak and more likely to break)
Tibia fracture (fracture of lower leg bone)
Drug ineffective

What are the common drug interactions of Doxycycline Hyclate and Ciprofloxacin Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Migraine (headache)
Back pain
Blood sodium decreased
Bone disorder
Depression
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Herpes zoster
Intervertebral disc protrusion (spinal disc protrusion)
Lyme disease (a bacterial infection that is spread to humans by infected ticks)

40-49:

Dry eye (lack of adequate tears)
Eye irritation
Hypophagia (reduced food intake)
Nausea (feeling of having an urge to vomit)
Pain
Skin tightness
Abdominal distension
Abdominal pain upper
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bladder disorder

50-59:

Leukocytosis (increased white blood cells)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Migraine with aura (headache with vision weakness)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Poisoning

60+:

Sinusitis (inflammation of sinus)
Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Herpes zoster
Infusion site vesicles (fluid- or air-filled cavity or sac at infusion site)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Nerve injury

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 18.52%
Immunodeficiency Common Variable: 10 people, 18.52%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 18.52%
High Blood Cholesterol: 5 people, 9.26%
Pain: 4 people, 7.41%
Nausea (feeling of having an urge to vomit): 4 people, 7.41%
Hiv Infection: 3 people, 5.56%
High Blood Pressure: 3 people, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.56%
Fungal Infection: 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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