Doxycycline hyclate and Dapsone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline hyclate (doxycycline hyclate) and Dapsone (dapsone). Common drug interactions include pyrexia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline hyclate and Dapsone. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline hyclate?

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 17,884 Doxycycline hyclate users. Check the latest studies of Doxycycline hyclate.

What is Dapsone?

Dapsone has active ingredients of dapsone. It is often used in dermatitis herpetiformis. eHealthMe is studying from 11,732 Dapsone users. Check the latest studies of Dapsone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

80 people who take Doxycycline hyclate and Dapsone together, and have interactions are studied.

Doxycycline hyclate and Dapsone drug interactions.

What are the common drug interactions of Doxycycline Hyclate and Dapsone, by gender? *:

female:

Pyrexia (fever)
Weight decreased
Arthropathy
Asthenia (weakness)
Blood glucose increased
Contusion (a type of hematoma of tissue in which capillaries)
Femur fracture
Gastric disorder (disease of stomach)
Glycosylated haemoglobin increased
Hepatic enzyme increased

male:

Chronic kidney disease
Emotional distress
Blood triglycerides increased
Bone metabolism disorder
Dyspnoea (difficult or laboured respiration)
Multiple fractures
Abdominal pain
Alopecia scarring (irreversible damage of the hair follicles, replacing them with scar tissue)
Ankle fracture
Bone density decreased

What are the common drug interactions of Doxycycline Hyclate and Dapsone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Drug resistance (reduction in effectiveness of a drug)
Emotional distress
Foot fracture
Hand fracture
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Pain
Papilloedema (optic disc swelling)
Renal failure (kidney dysfunction)

30-39:

Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Renal failure (kidney dysfunction)
Depression
Multiple fractures
Complications of transplanted kidney
Immunodeficiency

40-49:

Pain
Drug ineffective
Drug intolerance (drug sensitivity)
Hidradenitis (chronic disease of a type of sweat gland)
Mobility decreased (ability to move is reduced)
Scar
Skin lesion
Suicidal ideation
Wound secretion
Dizziness

50-59:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Metabolic syndrome (a combination of the medical disorders that, when occurring together, increase the risk of developing cardiovascular disease)
Pulmonary embolism (blockage of the main artery of the lung)
Tachyarrhythmia (disturbance of the heart rhythm in which the heart rate is abnormally increased)
Vomiting
Aphonia (inability to produce voice)
Bone density decreased
Bone disorder
Brain neoplasm malignant (brain cancer tumour)
Depression

60+:

Diarrhoea
Drug hypersensitivity
Localised infection (infection at the single location)
Myopathy (a muscular disease in which the muscle fibres do not function)
Plasma cell myeloma (cancer that begins in plasma cells)
Swelling
Cardiac failure
Appetite disorder (abnormal eating habits)
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)

What are the existing conditions these people have? *

Hiv Infection: 22 people, 27.50%
Multiple Myeloma (cancer of the plasma cells): 14 people, 17.50%
Immunodeficiency Common Variable: 9 people, 11.25%
Hidradenitis (chronic disease of a type of sweat gland): 8 people, 10.00%
Immune System Disorder: 6 people, 7.50%
B-Lymphocyte Abnormalities (abnormal population of b lymphocytes in the blood, bone marrow, or tissues): 6 people, 7.50%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 6.25%
Asthma: 5 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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