Doxycycline hyclate and Dulcolax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline hyclate (doxycycline hyclate) and Dulcolax (bisacodyl). Common drug interactions include rash among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline hyclate and Dulcolax. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline hyclate?

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 17,884 Doxycycline hyclate users. Check the latest studies of Doxycycline hyclate.

What is Dulcolax?

Dulcolax has active ingredients of bisacodyl. It is often used in constipation. eHealthMe is studying from 12,897 Dulcolax users. Check the latest studies of Dulcolax.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

50 people who take Doxycycline hyclate and Dulcolax together, and have interactions are studied.

Doxycycline hyclate and Dulcolax drug interactions.

What are the common drug interactions of Doxycycline Hyclate and Dulcolax, by gender? *:

female:

Rash
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Decreased appetite
Fall
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Nephrogenic anaemia (anaemia due to kidney disease)

male:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Pneumonia
Renal failure (kidney dysfunction)
Abdominal discomfort
Actinomyces test positive
Acute respiratory failure
Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)

What are the common drug interactions of Doxycycline Hyclate and Dulcolax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Contusion (a type of hematoma of tissue in which capillaries)
Death
Dry skin
Gastric disorder (disease of stomach)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Skin exfoliation (removal of the oldest dead skin cells)
Skin fissures (a crack in the skin)
Skin ulcer

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Chronic left ventricular failure (long lasting functional impairment of left ventricle of heart)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

50-59:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Cerebral artery stenosis (hardening of brain blood vessels)
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Clumsiness (a lack of coordination or elegance)
Confusional state
Decreased appetite

60+:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Decreased appetite
Fall
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Nephrogenic anaemia (anaemia due to kidney disease)
Pneumonia
Upper limb fracture

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 20.00%
Pain: 10 people, 20.00%
High Blood Pressure: 8 people, 16.00%
High Blood Cholesterol: 7 people, 14.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 10.00%
Nausea (feeling of having an urge to vomit): 5 people, 10.00%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 8.00%
Insomnia (sleeplessness): 4 people, 8.00%
Stress And Anxiety: 4 people, 8.00%
Lower Respiratory Tract Infection: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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