Doxycycline hyclate and Yaz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline hyclate (doxycycline hyclate) and Yaz (drospirenone; ethinyl estradiol). Common drug interactions include visual field defect among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline hyclate and Yaz. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline hyclate?

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 17,884 Doxycycline hyclate users. Check the latest studies of Doxycycline hyclate.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

On Jul, 04, 2026

92 people who take Doxycycline hyclate and Yaz together, and have interactions are studied.

Doxycycline hyclate and Yaz drug interactions.

What are the common drug interactions of Doxycycline Hyclate and Yaz, by gender? *:

female:

Visual field defect
Cardiomegaly (increased size of heart than normal)
Adverse event
Back injury
Bartonellosis (infectious disease produced by bacteria of the genus bartonella)
Blood creatinine increased
Brain stem infarction (brainstem stroke)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Embolic stroke (stroke due to obstruction due to an embolus)
Fibrin d dimer increased

male:

Anxiety
Emotional distress
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fatigue (feeling of tiredness)
Fear
Gallbladder disorder
Multiple myeloma (cancer of the plasma cells)
Muscle spasms (muscle contraction)
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)

What are the common drug interactions of Doxycycline Hyclate and Yaz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Oedema peripheral (superficial swelling)
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Emotional distress
General physical health deterioration (weak health status)
Iliac vein occlusion (narrowing of an iliac vein segment between the aortic bifurcation and the groin)
Muscular weakness (muscle weakness)
Pain
Gallbladder disorder

20-29:

Back pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Emotional distress
Abdominal pain upper
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Oedema peripheral (superficial swelling)
Pulmonary infarction (death of a small area of lung)
Anxiety
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)

30-39:

Vomiting
Nausea (feeling of having an urge to vomit)
Pulmonary embolism (blockage of the main artery of the lung)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Pain
Abdominal pain
Gallbladder disorder
Abdominal pain upper
Thrombosis (formation of a blood clot inside a blood vessel)
Cholecystitis chronic (long lasting infection of gallbladder)

40-49:

Pulmonary embolism (blockage of the main artery of the lung)
Injury
Pain
Fear
Emotional distress
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Cholecystitis chronic (long lasting infection of gallbladder)
Psychological trauma
Abdominal distension

50-59:

n/a

60+:

Anxiety
General physical health deterioration (weak health status)
Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Multiple myeloma (cancer of the plasma cells)
Muscle spasms (muscle contraction)
Pain in extremity
Sepsis (a severe blood infection that can lead to organ failure and death)
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls)
Adverse event

What are the existing conditions these people have? *

Premenstrual Syndrome: 17 people, 18.48%
Pain: 11 people, 11.96%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 9.78%
Headache (pain in head): 7 people, 7.61%
Depression: 6 people, 6.52%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 6.52%
Urinary Tract Infection: 5 people, 5.43%
Heavy Or Prolong Menstrual Bleeding: 5 people, 5.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

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