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Doxycycline and Kionex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline (doxycycline hyclate) and Kionex (sodium polystyrene sulfonate). Common drug interactions include somnolence among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline and Kionex. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

What is Kionex?

Kionex has active ingredients of sodium polystyrene sulfonate. eHealthMe is studying from 478 Kionex users. Check the latest studies of Kionex.

On Jul, 19, 2026

25 people who take Doxycycline and Kionex together, and have interactions are studied.

Doxycycline and Kionex drug interactions.

What are the common drug interactions of Doxycycline and Kionex, by gender? *:

female:

  1. Somnolence (a state of near-sleep, a strong desire for sleep)
  2. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  3. Upper limb fracture
  4. Chronic kidney disease
  5. Renal failure (kidney dysfunction)
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Anxiety
  8. Emotional distress
  9. Fatigue (feeling of tiredness)
  10. Nephrogenic anaemia (anaemia due to kidney disease)

male:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Weight decreased
  4. Anaemia (lack of blood)
  5. Anaemia of chronic disease
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Anxiety
  8. Bone density decreased
  9. Bone loss
  10. Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)

What are the common drug interactions of Doxycycline and Kionex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Chronic kidney disease

40-49:

  1. Chronic kidney disease
  2. Nephrogenic anaemia (anaemia due to kidney disease)
  3. Renal failure (kidney dysfunction)
  4. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  5. Anxiety
  6. Depression
  7. Emotional distress
  8. Fatigue (feeling of tiredness)
  9. Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
  10. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

50-59:

  1. Asthma
  2. Bone density decreased
  3. Chronic kidney disease
  4. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  5. Diabetes mellitus inadequate control
  6. Diabetic nephropathy (diabetic kidney disease)
  7. Emotional distress
  8. Multiple injuries
  9. Pain
  10. Pneumonia streptococcal (pneumonia, caused by streptococcus pneumoniae)

60+:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  4. Nephrogenic anaemia (anaemia due to kidney disease)
  5. Nausea (feeling of having an urge to vomit)
  6. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 52.00%
  2. High Blood Pressure: 12 people, 48.00%
  3. Indigestion: 10 people, 40.00%
  4. Hypersensitivity: 9 people, 36.00%
  5. Diabetes: 9 people, 36.00%
  6. High Blood Cholesterol: 9 people, 36.00%
  7. Pain: 8 people, 32.00%
  8. Fungal Infection: 8 people, 32.00%
  9. Depression: 7 people, 28.00%
  10. Hyperkalemia (damage to or disease of the kidney): 7 people, 28.00%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline and Kionex?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Doxycycline and Kionex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Kionex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Doxycycline and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Kionex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate and sodium polystyrene sulfonate (the active ingredients of Doxycycline and Kionex, respectively), and Doxycycline and Kionex (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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