Doxycycline and Lubiprostone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline (doxycycline hyclate) and Lubiprostone (lubiprostone). Common drug interactions include urinary tract infection among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline and Lubiprostone. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

What is Lubiprostone?

Lubiprostone has active ingredients of lubiprostone. eHealthMe is studying from 957 Lubiprostone users. Check the latest studies of Lubiprostone.



On Jul, 30, 2026

18 people who take Doxycycline and Lubiprostone together, and have interactions are studied.

Doxycycline and Lubiprostone drug interactions.

What are the common drug interactions of Doxycycline and Lubiprostone, by gender? *:

female:

  1. Urinary tract infection
  2. Acute respiratory failure
  3. Candida sepsis (candida in blood stream)
  4. Enuresis (repeated inability to control urination)
  5. Loss of consciousness
  6. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  7. Nasopharyngitis (inflammation of the nasopharynx)
  8. Nausea (feeling of having an urge to vomit)
  9. Snoring
  10. Surgery

male:

  1. Sepsis (a severe blood infection that can lead to organ failure and death)
  2. Confusional state
  3. Malignant neoplasm progression (cancer tumour came back)
  4. Anaemia (lack of blood)
  5. Hypoglycaemia (deficiency of glucose in the bloodstream)
  6. Hypoxia (low oxygen in tissues)
  7. Platelet count decreased
  8. Pneumonia
  9. Cardiac disorder
  10. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

What are the common drug interactions of Doxycycline and Lubiprostone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Enuresis (repeated inability to control urination)
  2. Loss of consciousness
  3. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  4. Nasopharyngitis (inflammation of the nasopharynx)
  5. Snoring
  6. Surgery
  7. Urinary tract infection
  8. Vomiting
  9. Wound
  10. Burning sensation

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Acute respiratory failure
  2. Candida sepsis (candida in blood stream)
  3. Hypoxia (low oxygen in tissues)
  4. Fall
  5. Femur fracture
  6. Gait disturbance
  7. Pain in extremity
  8. Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)

60+:

  1. Sepsis (a severe blood infection that can lead to organ failure and death)
  2. Confusional state
  3. Pathological fracture (broken bone caused by disease)
  4. Platelet count decreased
  5. Pulmonary embolism (blockage of the main artery of the lung)
  6. Pyrexia (fever)
  7. Urinary tract infection
  8. Cardiac disorder
  9. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  10. Death

What are the existing conditions these people have? *

  1. High Blood Pressure: 5 people, 27.78%
  2. Nausea (feeling of having an urge to vomit): 5 people, 27.78%
  3. Pain: 4 people, 22.22%
  4. Multiple Myeloma (cancer of the plasma cells): 4 people, 22.22%
  5. Wrist Fracture: 3 people, 16.67%
  6. Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 3 people, 16.67%
  7. Breast Infection: 3 people, 16.67%
  8. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 16.67%
  9. Constipation: 3 people, 16.67%
  10. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Doxycycline and Lubiprostone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lubiprostone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Doxycycline and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lubiprostone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate and lubiprostone (the active ingredients of Doxycycline and Lubiprostone, respectively), and Doxycycline and Lubiprostone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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