Doxycycline and Menaquinone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline (doxycycline hyclate) and Menaquinone (vitamin k). Common drug interactions include insomnia among females.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline and Menaquinone. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

What is Menaquinone?

Menaquinone has active ingredients of vitamin k. eHealthMe is studying from 775 Menaquinone users. Check the latest studies of Menaquinone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

13 people who take Doxycycline and Menaquinone together, and have interactions are studied.

Doxycycline and Menaquinone drug interactions.

What are the common drug interactions of Doxycycline and Menaquinone, by gender? *:

female:

Insomnia (sleeplessness)
Pain in extremity
Speech disorder
Wound infection
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Acquired oesophageal web (structural abnormalities in the oesophagus)
Chills (felling of cold)
Cough
Cystitis (inflammation of the wall of the bladder)

male:

n/a

What are the common drug interactions of Doxycycline and Menaquinone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cough
Diarrhoea
Dry eye (lack of adequate tears)
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Influenza
Insomnia (sleeplessness)
Memory impairment
Nocturnal dyspnoea (attacks of severe shortness of breath and coughing that generally occur at night)

50-59:

Pain in extremity
Urinary tract infection
Abdominal discomfort
Insomnia (sleeplessness)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Muscle twitching
Somnolence (a state of near-sleep, a strong desire for sleep)
Speech disorder
Cystitis (inflammation of the wall of the bladder)
Headache (pain in head)

60+:

Acquired oesophageal web (structural abnormalities in the oesophagus)
Chills (felling of cold)
Uterine polyp (a mass in the inner lining of the uterus)
Wound infection
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Spinal fusion surgery
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Precancerous cells present
Decreased appetite

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 53.85%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 15.38%
Gait Disturbance: 2 people, 15.38%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 7.69%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 7.69%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 1 person, 7.69%
Nasal Polyps (masses that develop in the lining of the nose): 1 person, 7.69%
Immunodeficiency: 1 person, 7.69%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 1 person, 7.69%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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