Doxycycline and Methylin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline (doxycycline hyclate) and Methylin (methylphenidate hydrochloride). Common drug interactions include dehydration among females and surgery among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline and Methylin. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

What is Methylin?

Methylin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,116 Methylin users. Check the latest studies of Methylin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

16 people who take Doxycycline and Methylin together, and have interactions are studied.

Doxycycline and Methylin drug interactions.

What are the common drug interactions of Doxycycline and Methylin, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Chest pain
Depressed mood
Diarrhoea
Fear
Hypokalaemia (low potassium)
Joint dislocation (a joint position is changed from normal position)
Sleep disorder
Small intestinal obstruction (blockage in small intestine)
Stress

male:

Surgery

What are the common drug interactions of Doxycycline and Methylin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Breast discharge
Bunion (a painful swelling on the first joint of the big toe)
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Headache (pain in head)
Hepatitis viral
Hypovolaemia (a decreased volume of circulating blood in the body)
Lymphadenopathy (disease or enlargement of lymph nodes)

50-59:

Dehydration (dryness resulting from the removal of water)
Hypotension (abnormally low blood pressure)
Intervertebral disc protrusion (spinal disc protrusion)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Limb injury
Nausea (feeling of having an urge to vomit)
Vomiting
Anxiety
Depressed mood

60+:

Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Impaired driving ability
Increased appetite
Intervertebral disc protrusion (spinal disc protrusion)
Nausea (feeling of having an urge to vomit)
Somnolence (a state of near-sleep, a strong desire for sleep)
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Vomiting

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 18.75%
Stress And Anxiety: 1 person, 6.25%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.25%
Panic Disorder: 1 person, 6.25%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 1 person, 6.25%
Depression: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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