Doxycycline and Msm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline (doxycycline hyclate) and Msm (methylsulfonylmethane). Common drug interactions include pneumonia among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline and Msm. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

What is Msm?

Msm has active ingredients of methylsulfonylmethane. It is often used in joint pain. eHealthMe is studying from 1,210 Msm users. Check the latest studies of Msm.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

11 people who take Doxycycline and Msm together, and have interactions are studied.

What are the common drug interactions of Doxycycline and Msm, by gender? *:

female:

Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
White blood cell count increased
Fatigue (feeling of tiredness)
Back pain
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Intervertebral disc protrusion (spinal disc protrusion)

male:

Fatigue (feeling of tiredness)
Fungal infection
Injection site bruising
Injection site pain
Localised infection (infection at the single location)
Mobility decreased (ability to move is reduced)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Restless legs syndrome (a powerful urge to move your legs)

What are the common drug interactions of Doxycycline and Msm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal distension
Abdominal pain lower
Diarrhoea
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

40-49:

Road traffic accident
Fatigue (feeling of tiredness)
Impaired driving ability

50-59:

Nausea (feeling of having an urge to vomit)

60+:

Back pain
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Intervertebral disc protrusion (spinal disc protrusion)
Oesophageal rupture (break in oesophagus)
Peripheral swelling
Rectal haemorrhage (bleeding from anus)

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 36.36%
Skin Infection: 1 person, 9.09%
Rashes (redness): 1 person, 9.09%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 9.09%
Immunodeficiency Common Variable: 1 person, 9.09%
Gastric Disorder (disease of stomach): 1 person, 9.09%
Eye Infection: 1 person, 9.09%
Cardiac Disorder: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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