Doxycycline and Ranolazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline (doxycycline hyclate) and Ranolazine (ranolazine). Common drug interactions include speech disorder among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline and Ranolazine. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

What is Ranolazine?

Ranolazine has active ingredients of ranolazine. eHealthMe is studying from 9,939 Ranolazine users. Check the latest studies of Ranolazine.

On Apr, 23, 2026

34 people who take Doxycycline and Ranolazine together, and have interactions are studied.

Doxycycline and Ranolazine drug interactions.

What are the common drug interactions of Doxycycline and Ranolazine, by gender? *:

female:

Speech disorder
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tardive dyskinesia (a disorder that involves involuntary movements)
Tibia fracture (fracture of lower leg bone)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary tract infection

male:

Agitation (state of anxiety or nervous excitement)
Chest pain
Asthenia (weakness)
Chronic kidney disease
Death
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Arthralgia (joint pain)
Balance disorder

What are the common drug interactions of Doxycycline and Ranolazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dysarthria (speech disorder)
Facial paralysis (loss of function of face muscle)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Muscular weakness (muscle weakness)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Pyelonephritis (inflammation of kidney caused by bacteria)
Pyrexia (fever)
Urinary tract infection
Confusional state

50-59:

Asthma
Chest pain
Dyspnoea (difficult or laboured respiration)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Chronic kidney disease
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Hypersensitivity

60+:

Pain in extremity
Vasculitis (inflammation of a blood vessel or blood vessels)
Dehydration (dryness resulting from the removal of water)
Dizziness
Fall
Neuropathy peripheral (surface nerve damage)
Asthenia (weakness)
Pain
Abdominal discomfort
Abdominal pain upper

What are the existing conditions these people have? *

Stable Angina (a constant chest pain): 4 people, 11.76%
Pain: 3 people, 8.82%
Asthma: 3 people, 8.82%
The Flu (the flu is caused by an influenza virus): 2 people, 5.88%
Pancreatic Neuroendocrine Tumor: 2 people, 5.88%
Nasopharyngitis (inflammation of the nasopharynx): 2 people, 5.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 5.88%
High Blood Pressure: 2 people, 5.88%
Heart Rate Irregular: 2 people, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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