Doxycycline and Sodium fluoride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline (doxycycline hyclate) and Sodium fluoride (fluoride). Common drug interactions include amnesia among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline and Sodium fluoride. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

What is Sodium fluoride?

Sodium fluoride has active ingredients of fluoride. It is often used in dental cavities. eHealthMe is studying from 1,216 Sodium fluoride users. Check the latest studies of Sodium fluoride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

62 people who take Doxycycline and Sodium fluoride together, and have interactions are studied.

Doxycycline and Sodium fluoride drug interactions.

What are the common drug interactions of Doxycycline and Sodium Fluoride, by gender? *:

female:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anti-cyclic citrullinated peptide antibody positive
Bone erosion
Confusional state
Delirium (wild excitement)
Depression
Diarrhoea
Disability
Foot deformity (functional disability of foot)
Glossodynia (a burning or painful sensation in the tongue)

male:

Anxiety
Renal failure (kidney dysfunction)
Cellulitis (infection under the skin)
Chronic kidney disease
Depression
Erythema (redness of the skin)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Nightmare (unpleasant dream)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Doxycycline and Sodium Fluoride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Bone density decreased
Emotional distress
Nephropathy (damage to or disease of a kidney)
Pain
Renal failure (kidney dysfunction)
Tooth loss

40-49:

Hepatic enzyme increased
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
Swelling
Arthralgia (joint pain)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Deep vein thrombosis postoperative (blood clot in a major vein that usually develops in the legs and/or pelvis after operation)
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)

50-59:

Mobility decreased (ability to move is reduced)
Malaise (a feeling of general discomfort or uneasiness)
Alopecia (absence of hair from areas of the body)
Anxiety
Asthma
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood cholesterol increased
Decreased appetite
Discomfort
Drug ineffective

60+:

Drug intolerance (drug sensitivity)
Dry eye (lack of adequate tears)
Cellulitis (infection under the skin)
Diarrhoea
Diplopia (double vision)
Early satiety (feeling full before completing a normal sized meal)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Erythema (redness of the skin)
Eye irritation
Eye pain

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 20 people, 32.26%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 19 people, 30.65%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 18 people, 29.03%
Psoriasis (immune-mediated disease that affects the skin): 16 people, 25.81%
Fibromyalgia (a long-term condition which causes pain all over the body): 14 people, 22.58%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 13 people, 20.97%
Indigestion: 13 people, 20.97%
Headache (pain in head): 13 people, 20.97%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 8.06%
Pain: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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