Doxycycline and Xenical drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxycycline (doxycycline hyclate) and Xenical (orlistat). Common drug interactions include dysphagia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Doxycycline and Xenical. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

What is Xenical?

Xenical has active ingredients of orlistat. It is often used in weight loss. eHealthMe is studying from 11,722 Xenical users. Check the latest studies of Xenical.

On Jul, 18, 2026

25 people who take Doxycycline and Xenical together, and have interactions are studied.

Doxycycline and Xenical drug interactions.

What are the common drug interactions of Doxycycline and Xenical, by gender? *:

female:

Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Dysuria (painful or difficult urination)
Ear disorder
Eyelid disorder
Chronic kidney disease
Arthralgia (joint pain)
Back pain
Fatigue (feeling of tiredness)

male:

Chronic kidney disease
Anaemia (lack of blood)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Urinary retention (the inability to completely or partially empty the bladder)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Gout (uric acid crystals building up in the body)

What are the common drug interactions of Doxycycline and Xenical, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bicytopenia (two parameters from the full blood count are low, the term bicytopenia can be used)
Macrocytosis (enlargement of red blood cells with near-constant haemoglobin concentration)
Spontaneous haematoma (blood collection with medical reason)
Abdominal pain
Arthralgia (joint pain)
Asthma
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest discomfort
Chest pain

40-49:

Arthralgia (joint pain)
Oedema peripheral (superficial swelling)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Chronic kidney disease
Dependence
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic nephropathy (diabetic kidney disease)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

50-59:

Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Vitamin b12 deficiency
Vomiting
Weight decreased
Wound
Back pain
Chronic kidney disease
Diarrhoea
Dyslipidaemia (abnormal amount of lipids)
Fatigue (feeling of tiredness)

60+:

Chronic kidney disease
Anxiety
Prostatomegaly (enlargement of the prostate)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Urinary retention (the inability to completely or partially empty the bladder)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Renal impairment (severely reduced kidney function)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 56.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 56.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 10 people, 40.00%
Depression: 9 people, 36.00%
Pain: 9 people, 36.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 32.00%
Insomnia (sleeplessness): 8 people, 32.00%
Infection: 6 people, 24.00%
Allergic Rhinitis: 5 people, 20.00%
Hypertriglyceridaemia (excess of triglycerides in the blood): 5 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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