Doxylamine succinate and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxylamine succinate (doxylamine succinate) and Zide (hydrochlorothiazide). Common drug interactions include hypoglycaemia among females and cardiac flutter among males.

The phase IV clinical study analyzes what interactions people have when they take Doxylamine succinate and Zide. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Doxylamine succinate?

Doxylamine succinate has active ingredients of doxylamine succinate. It is often used in insomnia. eHealthMe is studying from 2,851 Doxylamine succinate users. Check the latest studies of Doxylamine succinate.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,247 Zide users. Check the latest studies of Zide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

25 people who take Doxylamine succinate and Zide together, and have interactions are studied.

Doxylamine succinate and Zide drug interactions.

What are the common drug interactions of Doxylamine Succinate and Zide, by gender? *:

female:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Pain in extremity
Arthralgia (joint pain)
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Fatigue (feeling of tiredness)
Injection site pain
Knee arthroplasty

male:

Cardiac flutter (abnormal heart rhythm)
Death
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Presyncope
Renal injury (kidney injury)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chronic kidney disease

What are the common drug interactions of Doxylamine Succinate and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Drug abuse

60+:

Cardiac flutter (abnormal heart rhythm)
Death
Arterial stenosis (abnormal narrowing of the aortic valve in the heart)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blindness unilateral
Bone pain
Cardiac arrest
Chronic kidney disease
Cystitis (inflammation of the wall of the bladder)
Decreased appetite

What are the existing conditions these people have? *

Pain: 2 people, 8.00%
Joint Pain: 2 people, 8.00%
Asthma: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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