Dramamine and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dramamine (dimenhydrinate) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include memory impairment among females.

The phase IV clinical study analyzes what interactions people have when they take Dramamine and Excedrin. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Dramamine?

Dramamine has active ingredients of dimenhydrinate. It is often used in motion sickness. eHealthMe is studying from 1,386 Dramamine users. Check the latest studies of Dramamine.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

24 people who take Dramamine and Excedrin together, and have interactions are studied.

Dramamine and Excedrin drug interactions.

What are the common drug interactions of Dramamine and Excedrin, by gender? *:

female:

Memory impairment
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
White blood cell count decreased
Dysgeusia (disorder of the sense of taste)
Ear infection
Photosensitivity reaction
Pruritus (severe itching of the skin)
Diarrhoea
Muscle atrophy (a decrease in the mass of the muscle)
Myositis (inflammation of the muscles)

male:

n/a

What are the common drug interactions of Dramamine and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Alopecia (absence of hair from areas of the body)

20-29:

n/a

30-39:

Ear infection
Sinusitis (inflammation of sinus)

40-49:

Dysmenorrhoea (painful menstruation)
Hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Abdominal pain upper
Diarrhoea
Euphoric mood (excessively happy but may become angry or irritable)
Gastric disorder (disease of stomach)
Neuralgia (pain in one or more nerves)
Vomiting
Hypersomnia (excessive daytime sleepiness (eds))
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Upper limb fracture
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Electrolyte depletion (act of decreasing electrolyte markedly)
Fall
Foot fracture
Fractured coccyx (fracture tail bone)
Gallbladder disorder
Haemoglobin decreased
Memory impairment

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 33.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 33.33%
Migraine (headache): 5 people, 20.83%
Constipation: 5 people, 20.83%
Multiple Allergies (allergy to multiple agents): 3 people, 12.50%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 12.50%
Acne (skin problems that cause pimples): 3 people, 12.50%
Thyroid Diseases: 2 people, 8.33%
Stress And Anxiety: 2 people, 8.33%
Sneezing: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Dramamine and Excedrin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously