Dramamine and Promethazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dramamine (dimenhydrinate) and Promethazine (promethazine hydrochloride). Common drug interactions include pain among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Dramamine and Promethazine. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Dramamine?

Dramamine has active ingredients of dimenhydrinate. It is often used in motion sickness. eHealthMe is studying from 1,386 Dramamine users. Check the latest studies of Dramamine.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

15 people who take Dramamine and Promethazine together, and have interactions are studied.

Dramamine and Promethazine drug interactions.

What are the common drug interactions of Dramamine and Promethazine, by gender? *:

female:

Pain
General physical condition
Intervertebral disc degeneration (spinal disc degeneration)
Spinal osteoarthritis (joint cartilage loss in spine)
Allergy to arthropod bite
Benign intracranial hypertension (benign intracranial hypertension (bih) is a headache syndrome)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Depressed mood
Depression
Diarrhoea

male:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)

What are the common drug interactions of Dramamine and Promethazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Depressed mood
Depression

20-29:

Benign intracranial hypertension (benign intracranial hypertension (bih) is a headache syndrome)
Diplopia (double vision)
Headache (pain in head)
Injury
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Migraine (headache)
Pain
Papilloedema (optic disc swelling)
Tinnitus (a ringing in the ears)
Vision blurred

30-39:

Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hyperhidrosis (abnormally increased sweating)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Restlessness (not able to rest)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Energy increased
Fatigue (feeling of tiredness)

40-49:

Dysmenorrhoea (painful menstruation)

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pyrexia (fever)

60+:

Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Malaise (a feeling of general discomfort or uneasiness)
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Migraine (headache): 6 people, 40.00%
Pain: 3 people, 20.00%
Depression: 3 people, 20.00%
Stress And Anxiety: 3 people, 20.00%
Muscle Spasms (muscle contraction): 3 people, 20.00%
Indigestion: 2 people, 13.33%
Constipation: 2 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 13.33%
Headache (pain in head): 2 people, 13.33%
High Blood Pressure: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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