Drisdol and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Drisdol (ergocalciferol) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include renal failure among females.

The phase IV clinical study analyzes what interactions people have when they take Drisdol and Macrobid. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Drisdol?

Drisdol has active ingredients of ergocalciferol. It is often used in vitamin d. eHealthMe is studying from 1,741 Drisdol users. Check the latest studies of Drisdol.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

15 people who take Drisdol and Macrobid together, and have interactions are studied.

What are the common drug interactions of Drisdol and Macrobid, by gender? *:

female:

Renal failure (kidney dysfunction)
Chronic kidney disease
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Essential hypertension (primary hypertension)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hydronephrosis (water inside the kidney)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

male:

n/a

What are the common drug interactions of Drisdol and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain lower
Anaemia (lack of blood)
Bladder hypertrophy (bladder overgrowth- increase in cell size)
Cardiomyopathy (weakening of the heart muscle)
Chronic kidney disease
Delirium (wild excitement)
Detrusor sphincter dyssynergia (lack of external sphincter relaxation during voluntary voiding)
Device related infection
Escherichia sepsis (bacterial infection by escherichia coli)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)

40-49:

n/a

50-59:

Carcinoid tumour pulmonary (slow growing tumour)
Dyslipidaemia (abnormal amount of lipids)
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Lung neoplasm malignant (cancer tumour of lung)
Obesity (having too much body fat)
Renal failure (kidney dysfunction)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nausea (feeling of having an urge to vomit)

60+:

Chronic kidney disease
Dry skin
Skin swelling
Swelling
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Urticaria (rash of round, red welts on the skin that itch intensely)
Wheezing (a high-pitched whistling sound made while you breath)
Abdominal discomfort
Abdominal pain upper
Cardiogenic shock (inadequate circulation of blood)

What are the existing conditions these people have? *

Asthma: 6 people, 40.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 33.33%
Muscle Spasms (muscle contraction): 4 people, 26.67%
Anaemia (lack of blood): 3 people, 20.00%
Infection: 3 people, 20.00%
Gout (uric acid crystals building up in the body): 3 people, 20.00%
Blood Pressure Abnormal: 2 people, 13.33%
Cardiac Disorder: 2 people, 13.33%
Dyspnea (difficult or laboured breathing): 2 people, 13.33%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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