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Dronabinol and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dronabinol (dronabinol) and Phenergan (promethazine hydrochloride). Common drug interactions include hypokalaemia among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Dronabinol and Phenergan. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Dronabinol?

Dronabinol has active ingredients of dronabinol. eHealthMe is studying from 5,453 Dronabinol users. Check the latest studies of Dronabinol.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

On Jul, 19, 2026

71 people who take Dronabinol and Phenergan together, and have interactions are studied.

Dronabinol and Phenergan drug interactions.

What are the common drug interactions of Dronabinol and Phenergan, by gender? *:

female:

  1. Hypokalaemia (low potassium)
  2. Oedema peripheral (superficial swelling)
  3. Asthenia (weakness)
  4. Bacterial infection
  5. Chronic kidney disease
  6. Emotional distress
  7. Erythema (redness of the skin)
  8. Fall
  9. Fistula (an abnormal connection or passageway between two)
  10. Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)

male:

  1. Dehydration (dryness resulting from the removal of water)
  2. Hypoxia (low oxygen in tissues)
  3. Anxiety
  4. Bone pain
  5. Cardiac arrest
  6. Abdominal pain
  7. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  8. Arthralgia (joint pain)
  9. Asthenia (weakness)
  10. Bone density decreased

What are the common drug interactions of Dronabinol and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Bronchitis bacterial (inflammation of the mucous membrane in the bronchial tubes due to bacterial infection)

10-19:

  1. Dehydration (dryness resulting from the removal of water)
  2. Hypoxia (low oxygen in tissues)
  3. Diarrhoea
  4. Decreased appetite
  5. Faecal incontinence (a lack of control over passing stool)
  6. Impaired gastric emptying
  7. Weight decreased

20-29:

  1. Accidental needle stick
  2. Agitation (state of anxiety or nervous excitement)
  3. Anxiety
  4. Decreased appetite
  5. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  6. Dyspepsia (indigestion)
  7. Injection site haemorrhage (bleeding from injection site)
  8. Injection site pain
  9. Weight decreased
  10. Cytomegalovirus viraemia (cytomegalo virus in blood stream)

30-39:

  1. Anxiety
  2. Arthralgia (joint pain)
  3. Bone density decreased
  4. Depression
  5. Emotional distress
  6. Osteonecrosis (death of bone)
  7. Osteopenia (a condition where bone mineral density is lower than normal)
  8. Pain

40-49:

  1. Arthralgia (joint pain)
  2. Bone pain
  3. Cellulitis (infection under the skin)
  4. Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
  5. Gangrene (body tissue dies)
  6. Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
  7. Perineal abscess
  8. Sepsis (a severe blood infection that can lead to organ failure and death)
  9. Urinary tract infection
  10. Vulval abscess

50-59:

  1. Erythema (redness of the skin)
  2. Fall
  3. Gastrointestinal carcinoma (cancer of stomach or intestine)
  4. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  5. Haematuria (presence of blood in urine)
  6. Hair disorder
  7. Headache (pain in head)
  8. Hepatic pain (pain in liver)
  9. Hyperglycaemia (high blood sugar)
  10. Ligament rupture (tear in ligament)

60+:

  1. Pain
  2. Weight decreased
  3. Cough
  4. Dehydration (dryness resulting from the removal of water)
  5. Malignant neoplasm progression (cancer tumour came back)
  6. Oropharyngeal pain
  7. Pneumonia
  8. Respiratory tract infection viral
  9. Anaemia (lack of blood)
  10. Anxiety

What are the existing conditions these people have? *

  1. Pain: 17 people, 23.94%
  2. Stress And Anxiety: 15 people, 21.13%
  3. Immunodeficiency Common Variable: 10 people, 14.08%
  4. Nausea And Vomiting: 10 people, 14.08%
  5. Multiple Myeloma (cancer of the plasma cells): 10 people, 14.08%
  6. Constipation: 9 people, 12.68%
  7. Depression: 9 people, 12.68%
  8. Diarrhea: 8 people, 11.27%
  9. High Blood Pressure: 8 people, 11.27%
  10. High Blood Cholesterol: 6 people, 8.45%

* Approximation only. Some reports may have incomplete information.

Do you take Dronabinol and Phenergan?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Dronabinol and Phenergan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dronabinol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Phenergan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Dronabinol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Phenergan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on dronabinol and promethazine hydrochloride (the active ingredients of Dronabinol and Phenergan, respectively), and Dronabinol and Phenergan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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