Droxidopa and Comtan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Droxidopa (droxidopa) and Comtan (entacapone). Common drug interactions include delirium among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Droxidopa and Comtan. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Droxidopa?

Droxidopa has active ingredients of droxidopa. eHealthMe is studying from 1,093 Droxidopa users. Check the latest studies of Droxidopa.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

On Jul, 12, 2026

25 people who take Droxidopa and Comtan together, and have interactions are studied.

What are the common drug interactions of Droxidopa and Comtan, by gender? *:

female:

Delirium (wild excitement)
Delusion (a false belief or opinion)
Dyskinesia (abnormality or impairment of voluntary movement)
Hallucination (an experience involving the perception of something not present)
Blood alkaline phosphatase increased
Pubis fracture
Rib fracture
Road traffic accident
Fall
Dehydration (dryness resulting from the removal of water)

male:

Decreased appetite
Dehydration (dryness resulting from the removal of water)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory failure (inadequate gas exchange by the respiratory system)
Dyskinesia (abnormality or impairment of voluntary movement)
Cold sweat
Compression fracture (fracture due to pressure caused by injury)
Constipation
Death
Fall

What are the common drug interactions of Droxidopa and Comtan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Decreased appetite

30-39:

n/a

40-49:

Decreased appetite

50-59:

Cold sweat
Compression fracture (fracture due to pressure caused by injury)
Overdose
Pallor
Respiratory depression (respiration has a rate below 12 breaths)
Somnolence (a state of near-sleep, a strong desire for sleep)
Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

Dyskinesia (abnormality or impairment of voluntary movement)
Delirium (wild excitement)
Rib fracture
Road traffic accident
Fall
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Pneumonia
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Syncope (loss of consciousness with an inability to maintain postural tone)
Dopamine dysregulation syndrome (complication of the dopaminergic treatment in parkinson's disease)

What are the existing conditions these people have? *

Hypotension (abnormally low blood pressure): 3 people, 12.00%
Type 2 Diabetes: 2 people, 8.00%
Stress And Anxiety: 2 people, 8.00%
High Blood Pressure: 2 people, 8.00%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 8.00%
Drug Effect Decreased: 2 people, 8.00%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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