Duexis and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duexis (famotidine; ibuprofen) and Pepcid (famotidine). Common drug interactions include chronic kidney disease among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Duexis and Pepcid. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Duexis?

Duexis has active ingredients of famotidine; ibuprofen. It is often used in arthritis. eHealthMe is studying from 1,731 Duexis users. Check the latest studies of Duexis.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,775 Pepcid users. Check the latest studies of Pepcid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

87 people who take Duexis and Pepcid together, and have interactions are studied.

What are the common drug interactions of Duexis and Pepcid, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Bladder disorder
Hypertension (high blood pressure)
Nephrogenic anaemia (anaemia due to kidney disease)
Acute respiratory failure
Angiopathy (generic term for a disease of the blood vessels)
Anxiety
Asthenia (weakness)
Cardiogenic shock (inadequate circulation of blood)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Aggression
Cardiac arrest
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Gastric cancer (stomach cancer)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mania (a state of abnormally elevated or irritable mood)
Mood swings (an extreme or rapid change in mood)
Neoplasm malignant (cancer tumour)

What are the common drug interactions of Duexis and Pepcid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Depression
Aggression
Cardiac arrest
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Mania (a state of abnormally elevated or irritable mood)
Neoplasm malignant (cancer tumour)
Renal failure (kidney dysfunction)
Suicidal ideation
Mood swings (an extreme or rapid change in mood)

40-49:

Renal failure (kidney dysfunction)
Depression
Malaise (a feeling of general discomfort or uneasiness)
Multi-organ disorder (multiple organ disease)
Chronic kidney disease
Ill-defined disorder
Renal injury (kidney injury)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hyperkalaemia (damage to or disease of the kidney)
Renal tubular necrosis (death of kidney tubules)
Bladder disorder
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Angiopathy (generic term for a disease of the blood vessels)
Anxiety
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood pressure increased
Cough
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Flushing (the warm, red condition of human skin)
Gastric cancer (stomach cancer)
Heart rate increased
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Pain: 39 people, 44.83%
High Blood Pressure: 18 people, 20.69%
High Blood Cholesterol: 18 people, 20.69%
Cardiac Disorder: 15 people, 17.24%
Gout (uric acid crystals building up in the body): 13 people, 14.94%
Blood Pressure Abnormal: 10 people, 11.49%
Infection: 8 people, 9.20%
Fever: 7 people, 8.05%
Renal Disorder (kidney disease): 6 people, 6.90%
Nausea And Vomiting: 6 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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