Dulcolax and Pyridium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dulcolax (bisacodyl) and Pyridium (phenazopyridine hydrochloride). Common drug interactions include chronic kidney disease among females and bursitis infective among males.

The phase IV clinical study analyzes what interactions people have when they take Dulcolax and Pyridium. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Dulcolax?

Dulcolax has active ingredients of bisacodyl. It is often used in constipation. eHealthMe is studying from 12,897 Dulcolax users. Check the latest studies of Dulcolax.

What is Pyridium?

Pyridium has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,841 Pyridium users. Check the latest studies of Pyridium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

34 people who take Dulcolax and Pyridium together, and have interactions are studied.

Dulcolax and Pyridium drug interactions.

What are the common drug interactions of Dulcolax and Pyridium, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Central pain syndrome (neurological condition caused by damage or malfunction in the central nervous system)
Drug hypersensitivity
Calculus bladder (bladder stone)
Abdominal pain
Cardiac disorder
Cataract (clouding of the lens inside the eye)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)

male:

Bursitis infective (the bursa can become infected, this is called infected bursitis)
Cellulitis (infection under the skin)
Metastases to liver (cancer spreads to liver)
Metastases to peritoneum (cancer spreads to peritoneum)
Mobility decreased (ability to move is reduced)
Myopathy (a muscular disease in which the muscle fibres do not function)
Pain
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Blood creatine phosphokinase increased
Cholecystitis acute (rapid infection of gallbladder)

What are the common drug interactions of Dulcolax and Pyridium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Calculus bladder (bladder stone)
Cardiac disorder
Cataract (clouding of the lens inside the eye)
Hypertension (high blood pressure)
Kidney infection
Nephrolithiasis (calculi in the kidneys)
Paraplegia (paralysis of the legs and lower body)
Visual impairment

40-49:

Drug hypersensitivity
Ileus (a painful obstruction of the ileum or other part of the intestine)
Incision site infection (infection at incision site)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Surgery

50-59:

Central pain syndrome (neurological condition caused by damage or malfunction in the central nervous system)
Bursitis infective (the bursa can become infected, this is called infected bursitis)
Cellulitis (infection under the skin)
Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Abdominal pain
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Infusion related reaction
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Chronic kidney disease
Mobility decreased (ability to move is reduced)
Febrile neutropenia (fever with reduced white blood cells)
Gallbladder injury
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Lower limb fracture
Malaise (a feeling of general discomfort or uneasiness)
Malignant neoplasm progression (cancer tumour came back)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 20.59%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 14.71%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 5 people, 14.71%
Pain: 5 people, 14.71%
Depression: 4 people, 11.76%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 11.76%
Chronic Thyroiditis (long lasting inflammation of thyroid gland): 3 people, 8.82%
Infection: 3 people, 8.82%
Urinary Retention (the inability to completely or partially empty the bladder): 3 people, 8.82%
Gastric Ph Decreased: 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

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