Duloxetine hydrochloride and Lortab drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duloxetine hydrochloride (duloxetine hydrochloride) and Lortab (acetaminophen; hydrocodone bitartrate). Common drug interactions include ejection fraction among females and amnesia among males.

The phase IV clinical study analyzes what interactions people have when they take Duloxetine hydrochloride and Lortab. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Duloxetine hydrochloride?

Duloxetine hydrochloride has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 17,410 Duloxetine hydrochloride users. Check the latest studies of Duloxetine hydrochloride.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

On Jul, 29, 2026

39 people who take Duloxetine hydrochloride and Lortab together, and have interactions are studied.

Duloxetine hydrochloride and Lortab drug interactions.

What are the common drug interactions of Duloxetine Hydrochloride and Lortab, by gender? *:

female:

Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersensitivity
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Lip swelling
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neuralgia (pain in one or more nerves)
Obesity (having too much body fat)

male:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Loss of consciousness
Dizziness
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)
Eye disorder
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Headache (pain in head)

What are the common drug interactions of Duloxetine Hydrochloride and Lortab, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Affect lability (emotional incontinence)
Agitation (state of anxiety or nervous excitement)
Arthralgia (joint pain)
Cardiac disorder
Cardiomyopathy (weakening of the heart muscle)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Confusional state

40-49:

Arthralgia (joint pain)
Herpes zoster
Oedema peripheral (superficial swelling)
Pyrexia (fever)
Cataract (clouding of the lens inside the eye)
Drug ineffective
Fatigue (feeling of tiredness)
Immune system disorder
Joint swelling
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Hypoxia (low oxygen in tissues)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Ill-defined disorder
Injury
Insomnia (sleeplessness)
Limb discomfort (discomfort in leg)
Malaise (a feeling of general discomfort or uneasiness)
Menopausal symptoms

60+:

Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Anaemia (lack of blood)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Nausea (feeling of having an urge to vomit)
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Subdural haematoma (blood collects between the skull and the surface of the brain)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 15.38%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 12.82%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 10.26%
Hot Flush (sudden feelings of heat): 4 people, 10.26%
Stress And Anxiety: 3 people, 7.69%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 7.69%
Oral Cancer (mouth cancer): 2 people, 5.13%
Neuropathy Peripheral (surface nerve damage): 2 people, 5.13%
Mucosal Inflammation (infection of mucous membrane): 2 people, 5.13%
Irritable Bowel Syndrome: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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