Duloxetine hydrochloride and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duloxetine hydrochloride (duloxetine hydrochloride) and Nucynta (tapentadol hydrochloride). Common drug interactions include monocyte count increased among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Duloxetine hydrochloride and Nucynta. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Duloxetine hydrochloride?

Duloxetine hydrochloride has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 17,410 Duloxetine hydrochloride users. Check the latest studies of Duloxetine hydrochloride.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Jul, 09, 2026

43 people who take Duloxetine hydrochloride and Nucynta together, and have interactions are studied.

Duloxetine hydrochloride and Nucynta drug interactions.

What are the common drug interactions of Duloxetine Hydrochloride and Nucynta, by gender? *:

female:

Monocyte count increased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Oxygen saturation decreased
Rheumatoid factor increased
Therapeutic response decreased (less preventive response)
Pneumonia
Headache (pain in head)
Vomiting
Arthropathy
Dyshidrotic eczema (skin condition in which blisters develop on the soles of your feet and/or the palms of hands)

male:

Diarrhoea
Drug ineffective
Nephrolithiasis (calculi in the kidneys)
Sinus disorder (disease of sinus)
Constipation
Disability
Dyspepsia (indigestion)
Dysuria (painful or difficult urination)
Gait disturbance
Insomnia (sleeplessness)

What are the common drug interactions of Duloxetine Hydrochloride and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pneumonia
Arthropathy
Dyshidrotic eczema (skin condition in which blisters develop on the soles of your feet and/or the palms of hands)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Nerve injury
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Skin infection
Syncope (loss of consciousness with an inability to maintain postural tone)
Weight increased

40-49:

Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Colitis (inflammation of colon)
Diarrhoea
Drug ineffective
Gait disturbance
Headache (pain in head)
Hypertension (high blood pressure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Nausea (feeling of having an urge to vomit)

50-59:

Blood pressure systolic decreased
C-reactive protein increased
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
Depressed mood
Glycosylated haemoglobin increased
Granulocyte count increased
Monocyte count increased
Nausea (feeling of having an urge to vomit)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Oxygen saturation decreased

60+:

Drug ineffective
Diarrhoea
Sinus disorder (disease of sinus)
Abdominal discomfort
Acute myocardial infarction (acute heart attack)
Burning sensation
Cough
Death
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 16.28%
Sleep Disorder: 5 people, 11.63%
Multiple Myeloma (cancer of the plasma cells): 4 people, 9.30%
Stress And Anxiety: 3 people, 6.98%
Neuralgia (pain in one or more nerves): 3 people, 6.98%
Nausea (feeling of having an urge to vomit): 3 people, 6.98%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 6.98%
Immunodeficiency: 3 people, 6.98%
High Blood Pressure: 3 people, 6.98%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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