Duopa and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duopa (carbidopa; levodopa) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include urinary tract infection among females and urinary tract infection among males.

The phase IV clinical study analyzes what interactions people have when they take Duopa and Excedrin. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Duopa?

Duopa has active ingredients of carbidopa; levodopa. eHealthMe is studying from 8,208 Duopa users. Check the latest studies of Duopa.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

24 people who take Duopa and Excedrin together, and have interactions are studied.

What are the common drug interactions of Duopa and Excedrin, by gender? *:

female:

Urinary tract infection

male:

Urinary tract infection
Fall
Drug ineffective
Post procedural haematuria (post procedural blood in urine)
Abdominal pain upper
Abdominal pain
Arthralgia (joint pain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Escherichia sepsis (bacterial infection by escherichia coli)

What are the common drug interactions of Duopa and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abdominal pain upper
Device dislocation
Fall
Gastrointestinal infection (infection of stomach and intestine)

60+:

Malaise (a feeling of general discomfort or uneasiness)
Urinary tract infection
Anaemia (lack of blood)
Faeces discoloured
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematochezia (passage of stools containing blood)
Haemoglobin decreased
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Insomnia (sleeplessness)
Intestinal polyp (small growths in the bowel with the potential for further growth)

What are the existing conditions these people have? *

Parkinson's Disease: 16 people, 66.67%
Hallucinations (sensations that appear real but are created by your mind): 7 people, 29.17%
Delusion (a false belief or opinion): 6 people, 25.00%
Depression: 5 people, 20.83%
Pain: 3 people, 12.50%
High Blood Cholesterol: 3 people, 12.50%
Stress And Anxiety: 2 people, 8.33%
Prostatic Disorder: 2 people, 8.33%
Joint Pain: 2 people, 8.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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