Duphalac and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duphalac (lactulose) and Actonel (risedronate sodium). Common drug interactions include aspartate aminotransferase increased among females and apical granuloma among males.

The phase IV clinical study analyzes what interactions people have when they take Duphalac and Actonel. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Duphalac?

Duphalac has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 5,152 Duphalac users. Check the latest studies of Duphalac.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Jul, 15, 2026

34 people who take Duphalac and Actonel together, and have interactions are studied.

What are the common drug interactions of Duphalac and Actonel, by gender? *:

female:

Aspartate aminotransferase increased
Gamma-glutamyltransferase increased
Localised infection (infection at the single location)
Nausea (feeling of having an urge to vomit)
Osteitis (a general term for inflammation of bone)
Abdominal discomfort
Blood alkaline phosphatase increased
Device related infection
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Fall

male:

Apical granuloma (tumour of the apex of a nonvital tooth)
Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Chills (felling of cold)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Completed suicide (act of taking one's own life)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Headache (pain in head)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatocellular injury (liver injury)

What are the common drug interactions of Duphalac and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Apical granuloma (tumour of the apex of a nonvital tooth)
Completed suicide (act of taking one's own life)
Dyspnoea (difficult or laboured respiration)
Gingival ulceration (ulcer on gums)
Lung disorder (lung disease)
Osteitis (a general term for inflammation of bone)
Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Pain in jaw
Stomatitis necrotising (inflammation of mucous membrane of mouth with cell damage)

30-39:

n/a

40-49:

n/a

50-59:

Aspartate aminotransferase increased
Gamma-glutamyltransferase increased
Localised infection (infection at the single location)
Osteitis (a general term for inflammation of bone)
Blood alkaline phosphatase increased
Prothrombin time shortened
Alanine aminotransferase increased
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatic trauma (liver injury)

60+:

Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Apical granuloma (tumour of the apex of a nonvital tooth)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bladder dysfunction
Dyspepsia (indigestion)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Hepatic failure (liver failure)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)

What are the existing conditions these people have? *

Pain: 4 people, 11.76%
Multiple Myeloma (cancer of the plasma cells): 4 people, 11.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.82%
Hepatitis B: 3 people, 8.82%
Anaemia (lack of blood): 3 people, 8.82%
Depression: 3 people, 8.82%
Factor Viii Inhibition (suppression of factor viii): 3 people, 8.82%
Sleep Disorder: 3 people, 8.82%
Agitation (state of anxiety or nervous excitement): 3 people, 8.82%
Hyperkalemia (damage to or disease of the kidney): 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

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