Duphalac and Duragesic-100 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duphalac (lactulose) and Duragesic-100 (fentanyl). Common drug interactions include thrombocytopenia among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Duphalac and Duragesic-100. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Duphalac?

Duphalac has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 5,152 Duphalac users. Check the latest studies of Duphalac.

What is Duragesic-100?

Duragesic-100 has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 19,509 Duragesic-100 users. Check the latest studies of Duragesic-100.

On Jul, 19, 2026

81 people who take Duphalac and Duragesic-100 together, and have interactions are studied.

Duphalac and Duragesic-100 drug interactions.

What are the common drug interactions of Duphalac and Duragesic-100, by gender? *:

female:

Thrombocytopenia (decrease of platelets in blood)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Cardiac arrest
Overdose
Abdominal pain
Death
Malaise (a feeling of general discomfort or uneasiness)
Acute hepatic failure
Asthenia (weakness)

male:

Diarrhoea
Aspartate aminotransferase increased
Pneumonia
Blood bilirubin increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Dyspnoea (difficult or laboured respiration)
Thrombocytopenia (decrease of platelets in blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Duphalac and Duragesic-100, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hypokalaemia (low potassium)
Liver carcinoma ruptured (ruptured liver cancer tumour)
Aspartate aminotransferase increased
Abdominal pain
Diarrhoea
Hepatic failure (liver failure)
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

50-59:

Pneumonia
Septic shock (shock due to blood infection)
Abnormal behaviour
Acute hepatic failure
Alanine aminotransferase increased
Asthenia (weakness)
Blood calcium decreased
Blood fibrinogen increased
Blood potassium decreased
Blood pressure decreased

60+:

Blood bilirubin increased
Septic shock (shock due to blood infection)
Cardiac arrest
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
General physical health deterioration (weak health status)
Haemoglobin decreased
Overdose
Tachyarrhythmia (disturbance of the heart rhythm in which the heart rate is abnormally increased)
Abdominal pain
Acute respiratory failure

What are the existing conditions these people have? *

High Blood Pressure: 16 people, 19.75%
Abdominal Pain: 15 people, 18.52%
Hepatic Neoplasm Malignant (liver cancer): 14 people, 17.28%
Weakness: 13 people, 16.05%
Headache (pain in head): 13 people, 16.05%
Lung Cancer - Non-Small Cell (lung cancer): 12 people, 14.81%
Nausea (feeling of having an urge to vomit): 10 people, 12.35%
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 10 people, 12.35%
Hepatitis B: 10 people, 12.35%
Palmar-Plantar Erythrodysaesthesia Syndrome (hand-foot syndrome): 9 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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