Duphalac and Oxaliplatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duphalac (lactulose) and Oxaliplatin (oxaliplatin). Common drug interactions include hypokalaemia among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Duphalac and Oxaliplatin. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Duphalac?

Duphalac has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 5,152 Duphalac users. Check the latest studies of Duphalac.

What is Oxaliplatin?

Oxaliplatin has active ingredients of oxaliplatin. It is often used in colon cancer. eHealthMe is studying from 72,058 Oxaliplatin users. Check the latest studies of Oxaliplatin.

On Aug, 02, 2026

49 people who take Duphalac and Oxaliplatin together, and have interactions are studied.

Duphalac and Oxaliplatin drug interactions.

What are the common drug interactions of Duphalac and Oxaliplatin, by gender? *:

female:

Hypokalaemia (low potassium)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Febrile neutropenia (fever with reduced white blood cells)
Salivary hypersecretion (excess saliva secretion)
Stomatitis (inflammation of mucous membrane of mouth)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Femoral neck fracture (neck of femur bone fracture)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Pyrexia (fever)

male:

Abdominal pain
Hepatotoxicity (chemical-driven liver damage)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea at rest (difficult or laboured breathing during rest)
Gastrointestinal perforation (hole in the digestive tract)
Hepatic enzyme increased
Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Hyperkalaemia (damage to or disease of the kidney)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Duphalac and Oxaliplatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Lipase increased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Hyperkalaemia (damage to or disease of the kidney)
Nausea (feeling of having an urge to vomit)
Vomiting

40-49:

Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Hepatotoxicity (chemical-driven liver damage)
Ileal perforation
Neoplasm malignant (cancer tumour)

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Femoral neck fracture (neck of femur bone fracture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fall
General physical health deterioration (weak health status)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Thrombosis (formation of a blood clot inside a blood vessel)
Coagulopathy (blood's ability to clot is impaired)
Dysphagia (a condition in which swallowing is difficult or painful)
Femur fracture

60+:

Hypokalaemia (low potassium)
Salivary hypersecretion (excess saliva secretion)
Altered state of consciousness (altered state of mind)
Anaphylactic reaction (serious allergic reaction)
Capillaritis (inflamed capillaries under the skin)
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Death
Dyspnoea (difficult or laboured respiration)
Dyspnoea at rest (difficult or laboured breathing during rest)

What are the existing conditions these people have? *

Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 11 people, 22.45%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 7 people, 14.29%
Nausea (feeling of having an urge to vomit): 7 people, 14.29%
Abdominal Pain: 6 people, 12.24%
Diabetes: 6 people, 12.24%
Adenocarcinoma Pancreas (cancer of pancreas): 5 people, 10.20%
Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins): 5 people, 10.20%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 5 people, 10.20%
Itching: 5 people, 10.20%
Indigestion: 5 people, 10.20%

* Approximation only. Some reports may have incomplete information.

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