Duragesic-100 and Arava drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duragesic-100 (fentanyl) and Arava (leflunomide). Common drug interactions include nasopharyngitis among females and bone marrow failure among males.

The phase IV clinical study analyzes what interactions people have when they take Duragesic-100 and Arava. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Duragesic-100?

Duragesic-100 has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 19,509 Duragesic-100 users. Check the latest studies of Duragesic-100.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

On Jul, 09, 2026

75 people who take Duragesic-100 and Arava together, and have interactions are studied.

Duragesic-100 and Arava drug interactions.

What are the common drug interactions of Duragesic-100 and Arava, by gender? *:

female:

Nasopharyngitis (inflammation of the nasopharynx)
Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)
Onychoclasis (breaking of the nails)
Oral candidiasis (fungal infection of mouth)
Parotid gland enlargement
Renal disorder (kidney disease)
Respiratory failure (inadequate gas exchange by the respiratory system)
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Sialoadenitis (inflammation of a salivary gland)
Spinal column stenosis (narrowing of spinal column)

male:

Bone marrow failure
Lymphoma (cancer that begins in immune system cells)
Memory impairment
Nausea (feeling of having an urge to vomit)
Osteonecrosis of jaw (death of bone of jaw)
Sedation
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin cancer
Skin ulcer
Suicidal ideation

What are the common drug interactions of Duragesic-100 and Arava, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug toxicity
Accidental death
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Pulmonary congestion (congestion in the lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Breakthrough pain
Contusion (a type of hematoma of tissue in which capillaries)
Drug effect decreased
Excoriation (to tear or wear off the skin of)
Exostosis (formation of new bone on the surface of a bone)

40-49:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Hypertension (high blood pressure)
Hypoxia (low oxygen in tissues)

50-59:

Cutaneous lupus erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms)
Erythema annulare (redness of the skin with sign of inflammation or infection)
Rash macular (small, flat red spots)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Tooth fracture

60+:

Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Aortic valve disease
Arthralgia (joint pain)
Cardiac failure
Chest pain
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Skin ulcer
Abscess jaw (tooth abscess or root abscess)

What are the existing conditions these people have? *

Depression: 13 people, 17.33%
Osteoporosis (bones weak and more likely to break): 12 people, 16.00%
Breakthrough Pain: 12 people, 16.00%
High Blood Pressure: 8 people, 10.67%
Infection: 6 people, 8.00%
Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 8.00%
Gastric Ulcer (stomach ulcer): 6 people, 8.00%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 6 people, 8.00%
Constipation: 6 people, 8.00%
Diabetes: 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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