Duragesic and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duragesic (fentanyl) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include neuropathy peripheral among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Duragesic and Zosyn. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Duragesic?

Duragesic has active ingredients of fentanyl. eHealthMe is studying from 66,597 Duragesic users. Check the latest studies of Duragesic.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Aug, 01, 2026

65 people who take Duragesic and Zosyn together, and have interactions are studied.

What are the common drug interactions of Duragesic and Zosyn, by gender? *:

female:

Neuropathy peripheral (surface nerve damage)
Swelling
Urinary tract infection
Asthenia (weakness)
Back pain
Nausea (feeling of having an urge to vomit)
Weight decreased
Cardiac failure congestive
Osteonecrosis (death of bone)
Pyrexia (fever)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Chills (felling of cold)
Catheter site haemorrhage (bleeding at catheter site)
Chest pain
Colitis (inflammation of colon)
Ear disorder
Epistaxis (bleed from the nose)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Histiocytosis haematophagic

What are the common drug interactions of Duragesic and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Blood calcium decreased
Cardiac failure
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Depression
Diarrhoea
Dysarthria (speech disorder)
Electrocardiogram poor r-wave progression
Electrocardiogram qrs complex shortened
Haematocrit decreased

30-39:

Anxiety
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cardiac failure congestive
Catheter site haemorrhage (bleeding at catheter site)
Chills (felling of cold)
Colitis (inflammation of colon)
Ear disorder
Epistaxis (bleed from the nose)

40-49:

Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Oedema peripheral (superficial swelling)
Retroperitoneal lymphadenopathy (disease of lymph node between peritoneum and the posterior abdominal wall)
Venous occlusion (the blocking of venous return)
Venous thrombosis (blood clot (thrombus) that forms within a vein)
Abasia (inability to walk)
Bedridden
Diarrhoea

50-59:

Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Renal failure acute (rapid kidney dysfunction)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Sepsis (a severe blood infection that can lead to organ failure and death)
Acute respiratory failure
Bacterial infection
Blood bicarbonate increased
Blood chloride decreased
Blood sodium decreased

60+:

Lethargy (tiredness)
Bone disorder
Neuropathy peripheral (surface nerve damage)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis (death of bone)
Tooth extraction
Asthenia (weakness)
Back pain
Osteomyelitis (infection of bone)
Urinary tract infection

What are the existing conditions these people have? *

Pain: 10 people, 15.38%
Asthma: 9 people, 13.85%
Staphylococcal Infection (an infection with staphylococcus bacteria): 7 people, 10.77%
Nausea (feeling of having an urge to vomit): 7 people, 10.77%
Stress And Anxiety: 4 people, 6.15%
Nausea And Vomiting: 4 people, 6.15%
Multiple Myeloma (cancer of the plasma cells): 4 people, 6.15%
Depression: 4 people, 6.15%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 6.15%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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