Durezol and Adcirca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Durezol (difluprednate) and Adcirca (tadalafil). Common drug interactions include death among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Durezol and Adcirca. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Durezol?

Durezol has active ingredients of difluprednate. It is often used in uveitis. eHealthMe is studying from 3,441 Durezol users. Check the latest studies of Durezol.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

On Jul, 07, 2026

11 people who take Durezol and Adcirca together, and have interactions are studied.

What are the common drug interactions of Durezol and Adcirca, by gender? *:

female:

Death
Chronic kidney disease
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Respiratory distress (difficulty in breathing)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

male:

Acute respiratory failure
Fatigue (feeling of tiredness)
Cough
Death
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Faeces discoloured
Fall

What are the common drug interactions of Durezol and Adcirca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acute respiratory failure
Fatigue (feeling of tiredness)
Hospitalisation
Pneumococcal bacteraemia (infection confirmed by the isolation of streptococcus pneumoniae)
Pneumonia pneumococcal (pneumococcal pneumonia is a common but serious infection and inflammation of the lungs)
Septic shock (shock due to blood infection)

40-49:

n/a

50-59:

Respiratory distress (difficulty in breathing)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

60+:

Death
Dyspnoea (difficult or laboured respiration)
Chronic kidney disease
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Dyspepsia (indigestion)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 45.45%
Oedema (fluid collection in tissue): 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
High Blood Cholesterol: 2 people, 18.18%
Gout (uric acid crystals building up in the body): 2 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%
Vasculitis (inflammation of a blood vessel or blood vessels): 1 person, 9.09%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 1 person, 9.09%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 9.09%
Pain: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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