Durezol and Azelastine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Durezol (difluprednate) and Azelastine (azelastine hydrochloride). Common drug interactions include chronic kidney disease among females and contusion among males.

The phase IV clinical study analyzes what interactions people have when they take Durezol and Azelastine. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Durezol?

Durezol has active ingredients of difluprednate. It is often used in uveitis. eHealthMe is studying from 3,441 Durezol users. Check the latest studies of Durezol.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,400 Azelastine users. Check the latest studies of Azelastine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

35 people who take Durezol and Azelastine together, and have interactions are studied.

Durezol and Azelastine drug interactions.

What are the common drug interactions of Durezol and Azelastine, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Death
Acute left ventricular failure (heart attack)
Acute myocardial infarction (acute heart attack)
Acute respiratory failure
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

male:

Contusion (a type of hematoma of tissue in which capillaries)
Anxiety
Pain in extremity
Tooth loss
Bone density decreased
Chronic kidney disease
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Neck pain
Oropharyngeal pain
Skin mass

What are the common drug interactions of Durezol and Azelastine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Contusion (a type of hematoma of tissue in which capillaries)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Skin mass

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Emotional distress
Pain
Fatigue (feeling of tiredness)
Hip fracture
Osteoporosis (bones weak and more likely to break)
Tooth loss
Bone density decreased

50-59:

Chronic kidney disease
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Eye haemorrhage (bleeding in the eye)
Facial bones fracture (bone fracture of face)
Glaucoma (increased fluid pressure in the eye with vision loss)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Inflammation
Nephrogenic anaemia (anaemia due to kidney disease)
Pneumonia

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Aortic valve stenosis (narrowing of the aortic valve)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac arrest
Cardiac failure acute
Cardiac failure congestive
Cardiogenic shock (inadequate circulation of blood)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Death

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 25.71%
High Blood Pressure: 8 people, 22.86%
Pain: 7 people, 20.00%
Multiple Myeloma (cancer of the plasma cells): 6 people, 17.14%
Infection: 6 people, 17.14%
High Blood Cholesterol: 6 people, 17.14%
Hiv Infection: 4 people, 11.43%
Asthma: 4 people, 11.43%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 11.43%
Stress And Anxiety: 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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