Durezol and Cymbalta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Durezol (difluprednate) and Cymbalta (duloxetine hydrochloride). Common drug interactions include decreased activity among females and cataract among males.

The phase IV clinical study analyzes what interactions people have when they take Durezol and Cymbalta. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Durezol?

Durezol has active ingredients of difluprednate. It is often used in uveitis. eHealthMe is studying from 3,441 Durezol users. Check the latest studies of Durezol.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,974 Cymbalta users. Check the latest studies of Cymbalta.

On Aug, 04, 2026

53 people who take Durezol and Cymbalta together, and have interactions are studied.

What are the common drug interactions of Durezol and Cymbalta, by gender? *:

female:

Decreased activity
Dizziness
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fatigue (feeling of tiredness)
Headache (pain in head)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic steatosis (fatty liver disease)
Hyperhidrosis (abnormally increased sweating)
Injection site bruising

male:

Cataract (clouding of the lens inside the eye)
Pain
Pruritus (severe itching of the skin)
Pyrexia (fever)
Respiratory disorder (respiratory disease)
Skin burning sensation
Throat tightness
Abdominal pain upper
Abscess limb (limb infection)
Alopecia (absence of hair from areas of the body)

What are the common drug interactions of Durezol and Cymbalta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Abdominal pain lower
Arthralgia (joint pain)
Haematochezia (passage of stools containing blood)
Influenza
Malaise (a feeling of general discomfort or uneasiness)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Pruritus (severe itching of the skin)

30-39:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Gastroenteritis (inflammation of stomach and intestine)
Hypertension (high blood pressure)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Impaired gastric emptying
Leukocytosis (increased white blood cells)
Appendicitis (inflammation of the appendix)
Pancreatitis (inflammation of pancreas)
Rash

40-49:

Pain
Renal impairment (severely reduced kidney function)
Visual impairment
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cellulitis (infection under the skin)
Chronic kidney disease
Fall
Injury
Renal failure (kidney dysfunction)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)

50-59:

Abscess limb (limb infection)
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Blindness unilateral
Bradycardia (abnormally slow heart action)
Cataract (clouding of the lens inside the eye)
Chromatopsia (visual defect in which colourless objects appear to be tinged with colour)
Chronic kidney disease
Deformity (disfigurement)
Epistaxis (bleed from the nose)

60+:

Chronic kidney disease
Cataract (clouding of the lens inside the eye)
Pyrexia (fever)
Rash pruritic (redness with itching)
Respiratory disorder (respiratory disease)
Abdominal pain upper
Apnoea (suspension of external breathing)
Arthralgia (joint pain)
Asthenia (weakness)
Blood pressure decreased

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 30.19%
High Blood Pressure: 11 people, 20.75%
Pain: 8 people, 15.09%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 11.32%
Hypersensitivity: 6 people, 11.32%
High Blood Cholesterol: 5 people, 9.43%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 9.43%
Diabetes: 5 people, 9.43%
Immunodeficiency Common Variable: 5 people, 9.43%
Headache (pain in head): 4 people, 7.55%

* Approximation only. Some reports may have incomplete information.

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