Durezol and Opsumit drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Durezol (difluprednate) and Opsumit (macitentan). Common drug interactions include death among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Durezol and Opsumit. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Durezol?

Durezol has active ingredients of difluprednate. It is often used in uveitis. eHealthMe is studying from 3,441 Durezol users. Check the latest studies of Durezol.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

On Jul, 12, 2026

13 people who take Durezol and Opsumit together, and have interactions are studied.

What are the common drug interactions of Durezol and Opsumit, by gender? *:

female:

Death
Dyspnoea (difficult or laboured respiration)
Renal failure (kidney dysfunction)
Chronic kidney disease
Fatigue (feeling of tiredness)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Abdominal pain
Arthropathy
Back pain

male:

Acute respiratory failure
Anaemia (lack of blood)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Faeces discoloured
Fall
Fatigue (feeling of tiredness)
Gastritis (inflammation of stomach)

What are the common drug interactions of Durezol and Opsumit, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Death
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Pyrexia (fever)
Renal failure (kidney dysfunction)
Acute respiratory failure
Anaemia (lack of blood)
Balance disorder
Chills (felling of cold)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 53.85%
Oedema (fluid collection in tissue): 2 people, 15.38%
High Blood Cholesterol: 2 people, 15.38%
Gout (uric acid crystals building up in the body): 2 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 15.38%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 7.69%
Fever: 1 person, 7.69%
Constipation: 1 person, 7.69%
Cor Pulmonale Chronic (long lasting enlargement of the right ventricle of the heart): 1 person, 7.69%
Dizziness: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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