Durezol and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Durezol (difluprednate) and Protonix (pantoprazole sodium). Common drug interactions include cataract among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Durezol and Protonix. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Durezol?

Durezol has active ingredients of difluprednate. It is often used in uveitis. eHealthMe is studying from 3,441 Durezol users. Check the latest studies of Durezol.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

On Jul, 11, 2026

73 people who take Durezol and Protonix together, and have interactions are studied.

What are the common drug interactions of Durezol and Protonix, by gender? *:

female:

Cataract (clouding of the lens inside the eye)
Cellulitis (infection under the skin)
Chest discomfort
Chromatopsia (visual defect in which colourless objects appear to be tinged with colour)
Cystitis (inflammation of the wall of the bladder)
Eye haemorrhage (bleeding in the eye)
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Fungal infection
Haematuria (presence of blood in urine)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood pressure increased
Cardiac failure
Cardiac failure congestive
Cardiovascular disorder (heart diseases)
Deformity (disfigurement)
Dyspepsia (indigestion)
Intestinal obstruction
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the common drug interactions of Durezol and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Depression
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Anxiety
Depression
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Nephropathy (damage to or disease of a kidney)
Pulmonary embolism (blockage of the main artery of the lung)
Scrotal abscess (pus in scrotum)

50-59:

Metamorphopsia (a type of distorted vision in which a grid of straight lines appears wavy and parts of the grid may appear blank)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nerve injury
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Retinal haemorrhage (bleeding from retina)
Scar
Skin exfoliation (removal of the oldest dead skin cells)
Splenomegaly (enlargement of spleen)
T-lymphocyte count increased
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
White blood cell count increased
Intestinal obstruction
Mycotic allergy (fungal allergy)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Drug hypersensitivity
Headache (pain in head)
Urinary tract infection fungal
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

What are the existing conditions these people have? *

High Blood Pressure: 25 people, 34.25%
Pain: 23 people, 31.51%
High Blood Cholesterol: 20 people, 27.40%
Diabetes: 15 people, 20.55%
Depression: 12 people, 16.44%
Fluid Retention (an abnormal accumulation of fluid in the blood): 12 people, 16.44%
Asthma: 11 people, 15.07%
Stress And Anxiety: 10 people, 13.70%
Immune System Disorder: 9 people, 12.33%
Infection: 9 people, 12.33%

* Approximation only. Some reports may have incomplete information.

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