Dymista and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dymista (azelastine hydrochloride; fluticasone propionate) and Codeine (codeine sulfate). Common drug interactions include cushing's syndrome among females and klebsiella infection among males.

The phase IV clinical study analyzes what interactions people have when they take Dymista and Codeine. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Dymista?

Dymista has active ingredients of azelastine hydrochloride; fluticasone propionate. It is often used in allergies. eHealthMe is studying from 4,407 Dymista users. Check the latest studies of Dymista.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

28 people who take Dymista and Codeine together, and have interactions are studied.

What are the common drug interactions of Dymista and Codeine, by gender? *:

female:

Cushing's syndrome (obesity, a rounded face, increased fat)
Drug ineffective
Left ventricular dysfunction
Mean platelet volume decreased (less than normal average size of platelet cells in blood)
Platelet count increased
Seasonal allergy (allergic condition due to certain season)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Chronic kidney disease
Cough

male:

Klebsiella infection
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Multiple injuries
Depression
Panic attack
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the common drug interactions of Dymista and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood immunoglobulin e increased
Cushing's syndrome (obesity, a rounded face, increased fat)
Mean platelet volume decreased (less than normal average size of platelet cells in blood)
Platelet count increased
Seasonal allergy (allergic condition due to certain season)
Drug ineffective
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)

50-59:

Chronic kidney disease
Left ventricular dysfunction
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Multiple injuries
Depression
Panic attack
Drug hypersensitivity
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

60+:

Klebsiella infection
Fatigue (feeling of tiredness)
Depressed mood
Diarrhoea
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Eye disorder
Haemoglobin decreased
Headache (pain in head)
Hepatotoxicity (chemical-driven liver damage)

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 28.57%
Asthma: 6 people, 21.43%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 21.43%
Hyperkalemia (damage to or disease of the kidney): 4 people, 14.29%
Bone Pain: 4 people, 14.29%
Haemoglobin Decreased: 4 people, 14.29%
Seasonal Allergy (allergic condition due to certain season): 4 people, 14.29%
High Blood Cholesterol: 3 people, 10.71%
Tumor Lysis Syndrome: 3 people, 10.71%
Metastases To Bone (cancer spreads to bone): 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

Do you take Dymista and Codeine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously