Dymista and Fluoxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dymista (azelastine hydrochloride; fluticasone propionate) and Fluoxetine (fluoxetine hydrochloride). Common drug interactions include oedema peripheral among females and chest discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Dymista and Fluoxetine. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Dymista?

Dymista has active ingredients of azelastine hydrochloride; fluticasone propionate. It is often used in allergies. eHealthMe is studying from 4,407 Dymista users. Check the latest studies of Dymista.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,823 Fluoxetine users. Check the latest studies of Fluoxetine.

On Jul, 12, 2026

68 people who take Dymista and Fluoxetine together, and have interactions are studied.

Dymista and Fluoxetine drug interactions.

What are the common drug interactions of Dymista and Fluoxetine, by gender? *:

female:

Oedema peripheral (superficial swelling)
Peripheral swelling
Respiratory tract infection
Road traffic accident
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)
Swelling face
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Upper-airway cough syndrome
Sinus disorder (disease of sinus)

male:

Chest discomfort
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Hepatic failure (liver failure)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Renal cyst (kidney cyst)
Renal failure (kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Urinary retention (the inability to completely or partially empty the bladder)
Abdominal pain upper

What are the common drug interactions of Dymista and Fluoxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

20-29:

Blindness
Feeling drunk
Vision blurred
Dizziness
Feeling hot
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

30-39:

Hypotension (abnormally low blood pressure)
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
Premature delivery

40-49:

Chronic kidney disease
Arthralgia (joint pain)
Fall
Joint stiffness
Knee arthroplasty
Abscess limb (limb infection)
Aggression
Alopecia (absence of hair from areas of the body)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Blood potassium decreased

50-59:

Arthralgia (joint pain)
Gastrointestinal pain
Headache (pain in head)
Joint stiffness
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Vomiting
Swelling face

60+:

Death
Malaise (a feeling of general discomfort or uneasiness)
Renal failure (kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Urinary retention (the inability to completely or partially empty the bladder)
Vision blurred
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Chest injury
Chronic kidney disease
Drug ineffective

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 20.59%
Seasonal Allergy (allergic condition due to certain season): 9 people, 13.24%
Sinus Disorder (disease of sinus): 8 people, 11.76%
Asthma: 7 people, 10.29%
Hypersensitivity: 6 people, 8.82%
Stress And Anxiety: 5 people, 7.35%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 7.35%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 7.35%
Immune System Disorder: 5 people, 7.35%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 5 people, 7.35%

* Approximation only. Some reports may have incomplete information.

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