Dymista and Lidoderm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dymista (azelastine hydrochloride; fluticasone propionate) and Lidoderm (lidocaine). Common drug interactions include nausea among females and complex regional pain syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Dymista and Lidoderm. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Dymista?

Dymista has active ingredients of azelastine hydrochloride; fluticasone propionate. It is often used in allergies. eHealthMe is studying from 4,407 Dymista users. Check the latest studies of Dymista.

What is Lidoderm?

Lidoderm has active ingredients of lidocaine. It is often used in pain. eHealthMe is studying from 10,524 Lidoderm users. Check the latest studies of Lidoderm.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

41 people who take Dymista and Lidoderm together, and have interactions are studied.

What are the common drug interactions of Dymista and Lidoderm, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Disturbance in attention
Dysstasia (difficulty in standing)
Insomnia (sleeplessness)
Nervousness
Pustular psoriasis (raised bumps on the skin that are filled with pus)
Speech disorder
Therapeutic response unexpected
Chronic kidney disease

male:

Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Cough
Osteoporosis (bones weak and more likely to break)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Renal impairment (severely reduced kidney function)
Therapeutic response unexpected
Upper limb fracture
Dyspepsia (indigestion)
Abdominal discomfort
Cardiac failure

What are the common drug interactions of Dymista and Lidoderm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Anaemia (lack of blood)
Ataxia (loss of full control of bodily movements)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Dizziness
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Periodic limb movement disorder
Restless legs syndrome (a powerful urge to move your legs)
Scoliosis (a medical condition in which a person's spine is curved from side to side)

40-49:

Chronic kidney disease
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Injection site haemorrhage (bleeding from injection site)
Nausea (feeling of having an urge to vomit)
Rash vesicular (rash with a small bubble)
Swelling face

50-59:

Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Disturbance in attention
Dysstasia (difficulty in standing)
Insomnia (sleeplessness)
Nervousness
Pustular psoriasis (raised bumps on the skin that are filled with pus)
Speech disorder
Therapeutic response unexpected
Headache (pain in head)

60+:

Abdominal discomfort
Drug ineffective
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Neuropathy peripheral (surface nerve damage)
Respiratory tract infection
Urticaria (rash of round, red welts on the skin that itch intensely)
Cardiac failure
Cardiac failure congestive

What are the existing conditions these people have? *

Fibromyalgia (a long-term condition which causes pain all over the body): 12 people, 29.27%
Neuralgia (pain in one or more nerves): 9 people, 21.95%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 21.95%
High Blood Pressure: 7 people, 17.07%
Dyspnea (difficult or laboured breathing): 6 people, 14.63%
Insomnia (sleeplessness): 5 people, 12.20%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 5 people, 12.20%
Stress And Anxiety: 5 people, 12.20%
High Blood Cholesterol: 5 people, 12.20%
Nausea (feeling of having an urge to vomit): 5 people, 12.20%

* Approximation only. Some reports may have incomplete information.

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