Effexor xr and Cogentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor xr (venlafaxine hydrochloride) and Cogentin (benztropine mesylate). Common drug interactions include pancreatitis among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor xr and Cogentin. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

What is Cogentin?

Cogentin has active ingredients of benztropine mesylate. It is often used in tardive dyskinesia. eHealthMe is studying from 7,692 Cogentin users. Check the latest studies of Cogentin.

On Jul, 15, 2026

83 people who take Effexor xr and Cogentin together, and have interactions are studied.

Effexor xr and Cogentin drug interactions.

What are the common drug interactions of Effexor Xr and Cogentin, by gender? *:

female:

Pancreatitis (inflammation of pancreas)
Pain
Cardiac disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Hepatitis (inflammation of the liver)
Nausea (feeling of having an urge to vomit)
Suicidal ideation
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Neuropathy peripheral (surface nerve damage)
Neutropenia (an abnormally low number of neutrophils)

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Type 2 diabetes mellitus
Type 1 diabetes mellitus
Pruritus (severe itching of the skin)
Back pain
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Overdose
Cerebral atrophy (decrement in size of brain)

What are the common drug interactions of Effexor Xr and Cogentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Overdose

20-29:

Abnormal behaviour
Aggression
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Drug ineffective
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Intentional self-injury
Neutropenia (an abnormally low number of neutrophils)
Vision blurred
White blood cell count decreased
White blood cell count increased

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Cerebral atrophy (decrement in size of brain)
Pancreatitis (inflammation of pancreas)
Tooth impacted (a tooth that fails to fully pass through the gums)
Type 2 diabetes mellitus
Weight increased
Confusional state
Diabetes mellitus inadequate control
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperglycaemia (high blood sugar)

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Weight increased
Neuropathy peripheral (surface nerve damage)
Type 2 diabetes mellitus
Cardiac disorder
Chest pain
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Neoplasm (tumour)
Pruritus (severe itching of the skin)

50-59:

Pancreatitis (inflammation of pancreas)
Back pain
Hypertension (high blood pressure)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Type 1 diabetes mellitus
Blood triglycerides increased
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperglycaemia (high blood sugar)
Cardiac disorder

60+:

Intentional self-injury
Psychotic disorder
Suicidal ideation
Type 2 diabetes mellitus
Diarrhoea
Muscle twitching
Agitation (state of anxiety or nervous excitement)
Anger
Antisocial behaviour
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 22 people, 26.51%
Stress And Anxiety: 17 people, 20.48%
Sleep Disorder: 13 people, 15.66%
Agitation (state of anxiety or nervous excitement): 9 people, 10.84%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 8 people, 9.64%
Psychotic Disorder: 7 people, 8.43%
High Blood Pressure: 7 people, 8.43%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 7 people, 8.43%
Pain: 6 people, 7.23%
Urinary Retention (the inability to completely or partially empty the bladder): 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

Do you take Effexor xr and Cogentin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously