Effexor xr and Leflunomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor xr (venlafaxine hydrochloride) and Leflunomide (leflunomide). Common drug interactions include drug ineffective among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor xr and Leflunomide. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

On Jul, 11, 2026

38 people who take Effexor xr and Leflunomide together, and have interactions are studied.

Effexor xr and Leflunomide drug interactions.

What are the common drug interactions of Effexor Xr and Leflunomide, by gender? *:

female:

Drug ineffective
Drug hypersensitivity
Pain
Rash
Finger deformity (a deformed position of the finger)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Drug intolerance (drug sensitivity)
Insomnia (sleeplessness)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hepatic enzyme increased

male:

Cardiac failure congestive
Abdominal distension
Gout (uric acid crystals building up in the body)
Infection
Nephropathy (damage to or disease of a kidney)
Peripheral swelling
Psoriasis (immune-mediated disease that affects the skin)
Renal failure acute (rapid kidney dysfunction)
Diarrhoea
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Effexor Xr and Leflunomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Drug hypersensitivity
Drug ineffective
Drug intolerance (drug sensitivity)
Insomnia (sleeplessness)
Pain
Rash
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Finger deformity (a deformed position of the finger)
Hepatic enzyme increased

40-49:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysgeusia (disorder of the sense of taste)
Injection site swelling
Rash
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

50-59:

General physical condition
Syncope (loss of consciousness with an inability to maintain postural tone)
Chronic kidney disease
Drug hypersensitivity
Fatigue (feeling of tiredness)

60+:

Joint swelling
Arthralgia (joint pain)
Injection site haematoma (localized swelling filled with blood at injection site)
Rib fracture
Tendonitis (a condition that causes pain and swelling of tendons)
Tooth infection
Abdominal distension
Cardiac failure congestive
Diarrhoea
Drug ineffective

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 15.79%
Insomnia (sleeplessness): 5 people, 13.16%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 10.53%
Pain: 4 people, 10.53%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 7.89%
Osteoporosis (bones weak and more likely to break): 3 people, 7.89%
Gastric Disorder (disease of stomach): 3 people, 7.89%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 7.89%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 5.26%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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