Effexor xr and Primidone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor xr (venlafaxine hydrochloride) and Primidone (primidone). Common drug interactions include alopecia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor xr and Primidone. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

What is Primidone?

Primidone has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 10,474 Primidone users. Check the latest studies of Primidone.

On Jul, 25, 2026

62 people who take Effexor xr and Primidone together, and have interactions are studied.

Effexor xr and Primidone drug interactions.

What are the common drug interactions of Effexor Xr and Primidone, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Circadian rhythm sleep disorder (family of sleep disorders affecting, among other things, the timing of sleep)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)

male:

Dyspnoea (difficult or laboured respiration)
Intervertebral disc protrusion (spinal disc protrusion)
Limb injury
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Pneumonia
Rib fracture
Road traffic accident
Sepsis (a severe blood infection that can lead to organ failure and death)
Weight fluctuation
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)

What are the common drug interactions of Effexor Xr and Primidone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Back pain
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Cystitis (inflammation of the wall of the bladder)
Decreased appetite
Disease progression
Disturbance in attention
Hypoaesthesia (reduced sense of touch or sensation)
Memory impairment
Oedema peripheral (superficial swelling)

30-39:

n/a

40-49:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)

50-59:

Chronic kidney disease
Fall
Pneumonia
Psychological trauma
Renal injury (kidney injury)
Lower limb fracture
Malaise (a feeling of general discomfort or uneasiness)
Thrombosis (formation of a blood clot inside a blood vessel)
Blood cholesterol increased
Burning sensation

60+:

Fall
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Dysstasia (difficulty in standing)
Hallucination, visual (seeing things that aren't there)
Hypersomnia (excessive daytime sleepiness (eds))
Intestinal obstruction
Lung disorder (lung disease)
Paralysis
Renal disorder (kidney disease)
Renal pain (kidney pain)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 16 people, 25.81%
Pain: 15 people, 24.19%
Tremor (trembling or shaking movements in one or more parts of your body): 10 people, 16.13%
High Blood Cholesterol: 9 people, 14.52%
Neuropathy Peripheral (surface nerve damage): 7 people, 11.29%
Cardiac Disorder: 7 people, 11.29%
Diabetes: 7 people, 11.29%
Asthma: 6 people, 9.68%
Seasonal Affective Disorder (a type of depression that occurs at a certain time of the year, usually in the winter): 6 people, 9.68%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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