Effexor xr and Saphris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor xr (venlafaxine hydrochloride) and Saphris (asenapine maleate). Common drug interactions include insomnia among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor xr and Saphris. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

What is Saphris?

Saphris has active ingredients of asenapine maleate. It is often used in bipolar i disorder. eHealthMe is studying from 8,688 Saphris users. Check the latest studies of Saphris.

On Aug, 03, 2026

35 people who take Effexor xr and Saphris together, and have interactions are studied.

Effexor xr and Saphris drug interactions.

What are the common drug interactions of Effexor Xr and Saphris, by gender? *:

female:

Insomnia (sleeplessness)
Suicidal ideation
Weight increased
Restless legs syndrome (a powerful urge to move your legs)
Abnormal behaviour
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Drug administration error
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)

male:

Aggression
Drug hypersensitivity
Blood pressure increased
Confusional state
Hallucination (an experience involving the perception of something not present)
Ill-defined disorder
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Panic attack
Pruritus (severe itching of the skin)

What are the common drug interactions of Effexor Xr and Saphris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Death
Nausea (feeling of having an urge to vomit)
Vomiting

30-39:

Drug administration error
Aggression
Drooling (drop saliva uncontrollably from the mouth)
Fatigue (feeling of tiredness)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Oral discomfort (pain or irritation in mouth)
Suicidal ideation
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tongue discolouration (colour change of tongue)

40-49:

Colitis (inflammation of colon)
Confusional state
Dehydration (dryness resulting from the removal of water)
Drug hypersensitivity
Food poisoning (poison in food)
Gastrointestinal inflammation (inflammation of stomach and intestine)
Haematochezia (passage of stools containing blood)
Oral fungal infection
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)

50-59:

Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hostility
Insomnia (sleeplessness)
Libido decreased (loss of interest in sex)
Muscle rigidity (muscle stiffness)
Nausea (feeling of having an urge to vomit)
Panic reaction
Parkinson's disease

60+:

Drug hypersensitivity
Hallucination (an experience involving the perception of something not present)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Panic attack
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 22.86%
Stress And Anxiety: 6 people, 17.14%
Insomnia (sleeplessness): 5 people, 14.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 14.29%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 11.43%
Bipolar Disorder (mood disorder): 4 people, 11.43%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 5.71%
Post-Traumatic Stress Disorder: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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