Effexor and Fentora drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor (venlafaxine hydrochloride) and Fentora (fentanyl citrate). Common drug interactions include dystrophic calcification among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor and Fentora. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

What is Fentora?

Fentora has active ingredients of fentanyl citrate. eHealthMe is studying from 26,490 Fentora users. Check the latest studies of Fentora.

On Aug, 04, 2026

15 people who take Effexor and Fentora together, and have interactions are studied.

What are the common drug interactions of Effexor and Fentora, by gender? *:

female:

Dystrophic calcification (calcification occurring in degenerated or necrotic tissue)
Emotional distress
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Erythema (redness of the skin)
Exostosis (formation of new bone on the surface of a bone)
Exposed bone in jaw
Faecal incontinence (a lack of control over passing stool)
Fibula fracture
Gait disturbance
Gastritis (inflammation of stomach)

male:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Haemoglobin decreased
Headache (pain in head)
High density lipoprotein decreased
Hyperhidrosis (abnormally increased sweating)
Injury
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neck pain
Night sweats (sweating in night)

What are the common drug interactions of Effexor and Fentora, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pulmonary embolism (blockage of the main artery of the lung)

30-39:

n/a

40-49:

Anaemia (lack of blood)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Facet joint syndrome (problem with movement of the facet joints of the spine)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Intervertebral disc protrusion (spinal disc protrusion)
Oedema peripheral (superficial swelling)
Osteonecrosis of jaw (death of bone of jaw)

50-59:

Erythema (redness of the skin)
Exostosis (formation of new bone on the surface of a bone)
Exposed bone in jaw
Eyelid ptosis (falling of the upper or lower eyelid)
Facet joint syndrome (problem with movement of the facet joints of the spine)
Faecal incontinence (a lack of control over passing stool)
Fatigue (feeling of tiredness)
Fibula fracture
Emotional distress
Headache (pain in head)

60+:

Death
Dyspnoea exertional (breathlessness or shortness of breath)
Nervousness
Pain
Pleural effusion (water on the lungs)
Pruritus (severe itching of the skin)
Psychomotor hyperactivity (feelings of extreme restlessness)
Sepsis (a severe blood infection that can lead to organ failure and death)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

Pain: 6 people, 40.00%
Stress And Anxiety: 2 people, 13.33%
Mania (a state of abnormally elevated or irritable mood): 2 people, 13.33%
Agitation (state of anxiety or nervous excitement): 2 people, 13.33%
Asthma: 2 people, 13.33%
Bipolar Disorder (mood disorder): 2 people, 13.33%
Eating Disorder: 2 people, 13.33%
Headache (pain in head): 2 people, 13.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 13.33%
Irritability: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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