Effexor and Leukine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor (venlafaxine hydrochloride) and Leukine (sargramostim). Common drug interactions include pain among females and gastrooesophageal reflux disease among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor and Leukine. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

What is Leukine?

Leukine has active ingredients of sargramostim. eHealthMe is studying from 2,188 Leukine users. Check the latest studies of Leukine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

38 people who take Effexor and Leukine together, and have interactions are studied.

What are the common drug interactions of Effexor and Leukine, by gender? *:

female:

Pain
Neoplasm malignant (cancer tumour)
Renal failure (kidney dysfunction)
Abdominal pain
Pyrexia (fever)
Dizziness
Hypertension (high blood pressure)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Constipation

male:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Metastases to bone (cancer spreads to bone)
General physical health deterioration (weak health status)
Hypoaesthesia (reduced sense of touch or sensation)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Blood oestrogen increased
Decreased interest
Emotional distress
Gait disturbance
Gingival disorder (gum disease)

What are the common drug interactions of Effexor and Leukine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal discomfort
Colitis (inflammation of colon)
Diarrhoea
Injection site reaction
Nausea (feeling of having an urge to vomit)
Urinary tract infection

40-49:

Neutropenia (an abnormally low number of neutrophils)
Lethargy (tiredness)
Vomiting
Hypotension (abnormally low blood pressure)
Blood sodium decreased
Cerebral haemorrhage (bleeding within the brain)
Decreased appetite
Epistaxis (bleed from the nose)
Eye pain
Haemoglobin decreased

50-59:

Back pain
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Dysthymic disorder (mild chronic depression disorder)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Epistaxis (bleed from the nose)
Fall
Hyperglycaemia (high blood sugar)
Hypertension (high blood pressure)

60+:

Cough
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrophic vulvovaginitis (inflammation of the vulva)
Breath sounds
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac arrest
Cardiac failure congestive

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 12 people, 31.58%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 12 people, 31.58%
Pain: 10 people, 26.32%
Metastases To Bone (cancer spreads to bone): 9 people, 23.68%
Malignant Melanoma (skin cancer rises from melancytes): 6 people, 15.79%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 5 people, 13.16%
Prostate Cancer: 4 people, 10.53%
Nausea (feeling of having an urge to vomit): 4 people, 10.53%
Breast Cancer Female: 2 people, 5.26%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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