Effexor and Mepergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor (venlafaxine hydrochloride) and Mepergan (meperidine hydrochloride; promethazine hydrochloride). Common drug interactions include cardiac murmur among females and sinusitis among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor and Mepergan. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

What is Mepergan?

Mepergan has active ingredients of meperidine hydrochloride; promethazine hydrochloride. It is often used in pain. eHealthMe is studying from 211 Mepergan users. Check the latest studies of Mepergan.

On Aug, 05, 2026

12 people who take Effexor and Mepergan together, and have interactions are studied.

What are the common drug interactions of Effexor and Mepergan, by gender? *:

female:

Cardiac murmur (an heart sound in valve abnormality)
Cardiomyopathy (weakening of the heart muscle)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Contrast media reaction (reaction associated with the use of intravenous contrast material during radiology)
Crying
Decreased interest
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Deformity (disfigurement)
Dehydration (dryness resulting from the removal of water)

male:

Sinusitis (inflammation of sinus)
Abdominal pain
Dysphagia (a condition in which swallowing is difficult or painful)
Ear pain
Embolism venous (embolus may pass into the arterial system)
Exostosis (formation of new bone on the surface of a bone)
Exposed bone in jaw
Eye injury
Fibromyalgia (a long-term condition which causes pain all over the body)
Fistula (an abnormal connection or passageway between two)

What are the common drug interactions of Effexor and Mepergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Transverse sinus thrombosis (a blood clot in transverse sinus)
Vomiting
Aphasia (damage to the parts of the brain that control language)
Brain injury
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Crying
Haemorrhagic cerebral infarction (brain stroke with bleeding)
High risk pregnancy
Jugular vein thrombosis (clot in jugular vein)
Loss of consciousness

30-39:

n/a

40-49:

Chest pain
General symptom
Nausea (feeling of having an urge to vomit)
Peripheral vascular disorder
Rectal haemorrhage (bleeding from anus)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Road traffic accident
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic calcification (aortic calcification sign of heart valve disease)
Back pain

50-59:

Drug hypersensitivity
Pruritus (severe itching of the skin)
Rash papular (redness with papule)
Rash vesicular (rash with a small bubble)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

60+:

n/a

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 8.33%
Birth Control: 1 person, 8.33%
Asthma: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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