Effexor and Meridia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor (venlafaxine hydrochloride) and Meridia (sibutramine hydrochloride). Common drug interactions include fall among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor and Meridia. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

What is Meridia?

Meridia has active ingredients of sibutramine hydrochloride. It is often used in weight loss. eHealthMe is studying from 6,939 Meridia users. Check the latest studies of Meridia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

86 people who take Effexor and Meridia together, and have interactions are studied.

What are the common drug interactions of Effexor and Meridia, by gender? *:

female:

Fall
Osteonecrosis (death of bone)
Diarrhoea
Malignant neoplasm progression (cancer tumour came back)
Mitral valve incompetence (inefficient heart valve)
Cholecystitis (infection of gallbladder)
Rash
Swelling
Pyrexia (fever)
Pain

male:

Nausea (feeling of having an urge to vomit)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sedation
Unevaluable reaction
Drug screen positive
Dry mouth
Hypoaesthesia (reduced sense of touch or sensation)
Jaundice cholestatic

What are the common drug interactions of Effexor and Meridia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug screen positive
Menstrual disorder (disease of menstrual cycle)

30-39:

Nausea (feeling of having an urge to vomit)
Weight increased
Arthralgia (joint pain)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Malaise (a feeling of general discomfort or uneasiness)
Oedema lower limb (fluid collection in tissue of lower leg)
Pain
Restlessness (not able to rest)
Abdominal distension
Activities of daily living impaired

40-49:

Pyrexia (fever)
Cardiomegaly (increased size of heart than normal)
Chest discomfort
Chest pain
Cough
Dilatation ventricular
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Gingival ulceration (ulcer on gums)
Haematemesis (vomiting of blood)
Headache (pain in head)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypoaesthesia (reduced sense of touch or sensation)
Impaired healing
Inflammation
Lymphadenitis (inflammation or enlargement of a lymph node)
Lymphadenopathy (disease or enlargement of lymph nodes)
Metastases to ovary (cancer spreads to ovary)

60+:

Fatigue (feeling of tiredness)
Abdominal pain upper
Fall
Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the existing conditions these people have? *

Stress And Anxiety: 22 people, 25.58%
Sleep Disorder: 16 people, 18.60%
Pain: 13 people, 15.12%
High Blood Cholesterol: 11 people, 12.79%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 11.63%
Thyroid Diseases: 9 people, 10.47%
Asthma: 9 people, 10.47%
Gout (uric acid crystals building up in the body): 9 people, 10.47%
Oedema (fluid collection in tissue): 9 people, 10.47%
Metastases To Bone (cancer spreads to bone): 9 people, 10.47%

* Approximation only. Some reports may have incomplete information.

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