Effexor and Prolixin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor (venlafaxine hydrochloride) and Prolixin (fluphenazine hydrochloride). Common drug interactions include insomnia among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor and Prolixin. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

What is Prolixin?

Prolixin has active ingredients of fluphenazine hydrochloride. It is often used in schizoaffective disorder. eHealthMe is studying from 1,262 Prolixin users. Check the latest studies of Prolixin.

On Jul, 26, 2026

37 people who take Effexor and Prolixin together, and have interactions are studied.

What are the common drug interactions of Effexor and Prolixin, by gender? *:

female:

Insomnia (sleeplessness)
Melaena (the passage of black, tarry stools)
Neck pain
Neuropathy peripheral (surface nerve damage)
Otitis externa (external ear infection)
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)
Pyrexia (fever)
Restless legs syndrome (a powerful urge to move your legs)
Tendonitis (a condition that causes pain and swelling of tendons)
Vaginal infection

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Weight increased
Dizziness
Drug ineffective
Erectile dysfunction
Glycosylated haemoglobin increased
Gynaecomastia (enlargement of the gland tissue of the male breast)
Haematochezia (passage of stools containing blood)
Hepatomegaly (abnormal enlargement of the liver)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

What are the common drug interactions of Effexor and Prolixin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anger
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Suicidal ideation
Type 2 diabetes mellitus
Weight increased
Sedation

30-39:

Lethargy (tiredness)
Abnormal behaviour
Abnormal dreams
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Affect lability (emotional incontinence)
Anger
Antisocial behaviour
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Atelectasis (partial or complete collapse of the lung)

40-49:

Dyspnoea exertional (breathlessness or shortness of breath)
Low density lipoprotein increased (cholesterol increased in blood)
Overweight
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Rectal haemorrhage (bleeding from anus)
Weight increased
Diabetes mellitus inadequate control
Diabetic vascular disorder (diseases of the blood vessels due to diabetes)
Neuropathy peripheral (surface nerve damage)
Adverse drug reaction

50-59:

Dizziness
Type 2 diabetes mellitus
Otitis externa (external ear infection)
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)
Pyrexia (fever)
Restless legs syndrome (a powerful urge to move your legs)
Tendonitis (a condition that causes pain and swelling of tendons)
Vaginal infection
Otitis media (inflammation of the middle ear)
Weight increased

60+:

n/a

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 16.22%
Sleep Disorder: 5 people, 13.51%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 10.81%
Bipolar Disorder (mood disorder): 4 people, 10.81%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 10.81%
Mood Swings (an extreme or rapid change in mood): 3 people, 8.11%
High Blood Pressure: 3 people, 8.11%
Quit Smoking: 3 people, 8.11%
Pain: 3 people, 8.11%
Appetite Disorder (abnormal eating habits): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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