Effexor and Surmontil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor (venlafaxine hydrochloride) and Surmontil (trimipramine maleate). Common drug interactions include tremor among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor and Surmontil. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

What is Surmontil?

Surmontil has active ingredients of trimipramine maleate. It is often used in insomnia. eHealthMe is studying from 693 Surmontil users. Check the latest studies of Surmontil.

On Jul, 18, 2026

32 people who take Effexor and Surmontil together, and have interactions are studied.

Effexor and Surmontil drug interactions.

What are the common drug interactions of Effexor and Surmontil, by gender? *:

female:

Tremor (trembling or shaking movements in one or more parts of your body)
Drug ineffective
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Restlessness (not able to rest)
Flatulence (flatus expelled through the anus)
Hyposmia (impairment of the sense of smell)
Abdominal distension
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Confusional state
Dysarthria (speech disorder)

male:

Fatigue (feeling of tiredness)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug addiction
Drug exposure during pregnancy
Drug ineffective
Erectile dysfunction
Feeling hot
Impaired self-care
Rectal tenesmus (a feeling of incomplete defecation)
Rigors (an episode of shaking or exaggerated shivering)

What are the common drug interactions of Effexor and Surmontil, by age (0-1 to 60+)? *:

0-1:

Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Drug exposure during pregnancy

2-9:

n/a

10-19:

n/a

20-29:

Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Erythrocyte sedimentation rate increased
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Headache (pain in head)
Weakness
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Blood pressure increased
Drug ineffective
Electrocardiogram abnormal

30-39:

Epistaxis (bleed from the nose)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Sweating increased (excess sweating)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Thrombocytopenia (decrease of platelets in blood)
Ventricular fibrillation (abnormally irregular heart rhythm)
Vomiting

40-49:

Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Completed suicide (act of taking one's own life)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Feeling hot
Overdose
Rectal tenesmus (a feeling of incomplete defecation)
Restlessness (not able to rest)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting

50-59:

Tremor (trembling or shaking movements in one or more parts of your body)
Restlessness (not able to rest)
Abdominal distension
Drug ineffective
Dyspepsia (indigestion)
Hot flush (sudden feelings of heat)
Breast cancer
Drug addiction
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Peripheral neuropathy (damage to nerves of the peripheral nervous system)

60+:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Flatulence (flatus expelled through the anus)
Atrophic glossitis (smooth tongue)
Breast mass
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Mouth ulceration (mouth ulcers)
Muscle spasms (muscle contraction)

What are the existing conditions these people have? *

Pain: 3 people, 9.38%
Type 2 Diabetes: 2 people, 6.25%
High Blood Pressure: 2 people, 6.25%
Enterobacter Infection (infection caused by bacteria of the family enterobacteriaceae): 2 people, 6.25%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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