Effexor and Uptravi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor (venlafaxine hydrochloride) and Uptravi (selexipag). Common drug interactions include nasal congestion among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor and Uptravi. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

What is Uptravi?

Uptravi has active ingredients of selexipag. eHealthMe is studying from 26,576 Uptravi users. Check the latest studies of Uptravi.

On Aug, 03, 2026

40 people who take Effexor and Uptravi together, and have interactions are studied.

What are the common drug interactions of Effexor and Uptravi, by gender? *:

female:

Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Wheezing (a high-pitched whistling sound made while you breath)
Back pain
Dehydration (dryness resulting from the removal of water)
Dysphonia (speech disorder attributable to a disorder of phonation)
Hospitalisation
Pyrexia (fever)
Haematochezia (passage of stools containing blood)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Heart rate increased

male:

Headache (pain in head)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Back pain
Blood creatinine increased
Brain abscess
Chest pain
Electric shock
Erythema (redness of the skin)
Glomerulonephritis (a group of conditions that affect parts of the kidneys called glomeruli)
Gout (uric acid crystals building up in the body)

What are the common drug interactions of Effexor and Uptravi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Diarrhoea
Headache (pain in head)
Pain in jaw
Arthralgia (joint pain)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Pulmonary embolism (blockage of the main artery of the lung)
Vomiting
Abdominal distension
Ascites (accumulation of fluid in the abdominal cavity)

50-59:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Presyncope
Abdominal discomfort
Blood glucose increased
Fluid overload (too much fluid in the blood)
Hyperhidrosis (abnormally increased sweating)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Rash pruritic (redness with itching)
Bone pain
Haemoglobin decreased

60+:

Dyspnoea (difficult or laboured respiration)
Dehydration (dryness resulting from the removal of water)
Dysphonia (speech disorder attributable to a disorder of phonation)
Fatigue (feeling of tiredness)
Muscular weakness (muscle weakness)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pain
Pain in jaw
Wheezing (a high-pitched whistling sound made while you breath)
Dizziness

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 33 people, 82.50%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 7 people, 17.50%
Pain: 4 people, 10.00%
Autoimmune Hepatitis: 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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