Effexor and Zonisamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor (venlafaxine hydrochloride) and Zonisamide (zonisamide). Common drug interactions include dysgeusia among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor and Zonisamide. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

On Jul, 11, 2026

75 people who take Effexor and Zonisamide together, and have interactions are studied.

Effexor and Zonisamide drug interactions.

What are the common drug interactions of Effexor and Zonisamide, by gender? *:

female:

Dysgeusia (disorder of the sense of taste)
Flatulence (flatus expelled through the anus)
Abasia (inability to walk)
Abdominal discomfort
Abnormal behaviour
Abortion spontaneous (naturally occurring miscarriage)
Ageusia (loss of taste functions of the tongue)
Alopecia (absence of hair from areas of the body)
Anger
Arthritis (form of joint disorder that involves inflammation of one or more joints)

male:

Headache (pain in head)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Renal failure (kidney dysfunction)
Vomiting
Blood pressure increased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bruxism (habitual grinding of the teeth, typically during sleep)
Dizziness
Drug ineffective
Enuresis (repeated inability to control urination)

What are the common drug interactions of Effexor and Zonisamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Thrombosis (formation of a blood clot inside a blood vessel)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Vomiting

20-29:

Pneumonia
Fatigue (feeling of tiredness)
Impaired gastric emptying
Myalgia (muscle pain)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

30-39:

Chronic kidney disease
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Decreased appetite
Diarrhoea
Dizziness
Drug ineffective
Foot fracture
Hangover
Head discomfort
Headache (pain in head)

40-49:

Headache (pain in head)
Memory impairment
Pyrexia (fever)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug hypersensitivity
Drug ineffective
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Adverse drug reaction

50-59:

Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Diplopia (double vision)
Dysarthria (speech disorder)
Facial bones fracture (bone fracture of face)
Fatigue (feeling of tiredness)
Gait disturbance
Hemiparesis (weakness on one side of the body)
Incontinence (lack of moderation or self-control)

60+:

Blood pressure increased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Cardiac flutter (abnormal heart rhythm)
Headache (pain in head)
Injection site pain
Palpitations (feelings or sensations that your heart is pounding or racing)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 27 people, 36.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 14.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 13.33%
Migraine (headache): 10 people, 13.33%
Stress And Anxiety: 7 people, 9.33%
Pain: 7 people, 9.33%
Sleep Disorder: 6 people, 8.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 8.00%
Headache (pain in head): 6 people, 8.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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